DegronMD

Uniprot ID: Q9Y3L3

Source protein: SH3 domain-binding protein 1

Source gene: SH3BP1

Class: DEG_COP1_1

Location: 496:507

E3 ligase: COP1

DEGRON score: 0.9134

ASA_SCORE: 94.6583

COIL: 0.906

CONS_SCORE: 0.3733

DSS_SCORE: 0.6171

HELIX: 0.0828

FCONS_SCORE: 1.1052

RIG_SCORE: 0.6593

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S501F	TCGA-64-5774	LUAD	TCGA	SEELPSTAVPTP	DEG_COP1_1	0.7982
p.S501C	SIDM01042	Breast Carcinoma	GDSC	SEELPSTAVPTP	DEG_COP1_1	0.7541
p.S501C	ACH-001065	Breast Cancer	CCLE	SEELPSTAVPTP	DEG_COP1_1	0.7541
p.S501C	EVSA-T	breast	COSMIC	SEELPSTAVPTP	DEG_COP1_1	0.7541
p.A507V	DO233649	GACA	ICGC	SEELPSTAVPTP	DEG_COP1_1	0.6936
p.P500L	ACH-000173	Endometrial/Uterine Cancer	CCLE	SEELPSTAVPTP	DEG_COP1_1	0.6471
p.T502I	SIDM01609	Endometrial Carcinoma	GDSC	SEELPSTAVPTP	DEG_COP1_1	0.5966
p.T502I	ACH-000972	Endometrial/Uterine Cancer	CCLE	SEELPSTAVPTP	DEG_COP1_1	0.5966
p.R493H	DO13635	GBM	ICGC	SEELPSTAVPTP	DEG_COP1_1	0.25
p.S491L	DO41572	UCEC	ICGC	SEELPSTAVPTP	DEG_COP1_1	0.1944
p.P513T	TCGA-IR-A3LA	CESC	TCGA	SEELPSTAVPTP	DEG_COP1_1	0.1667
p.A489V	DO38404	STAD	ICGC	SEELPSTAVPTP	DEG_COP1_1	0.1389
p.E489D	DO229227	THCA	ICGC	SEELPSTAVPTP	DEG_COP1_1	0.1389
p.P515L	TCGA-F4-6570	COAD	TCGA	SEELPSTAVPTP	DEG_COP1_1	0.1111
p.R515C	DO233918	GACA	ICGC	SEELPSTAVPTP	DEG_COP1_1	0.1111
p.P487S	DO52231	LIHC	ICGC	SEELPSTAVPTP	DEG_COP1_1	0.0833
p.P487L	DO38123	SKCM	ICGC	SEELPSTAVPTP	DEG_COP1_1	0.0833
p.P517A	ACH-000988	Endometrial/Uterine Cancer	CCLE	SEELPSTAVPTP	DEG_COP1_1	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3L3	SH3 domain-binding protein 1	DEG_COP1_1	496:507	SEELPSTAVPTP	COP1	0.9134	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons