DegronMD - Q9Y3L3(SH3BP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S501F	TCGA-64-5774	LUAD	TCGA	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation altering degron motif	0.7982
p.P515L	TCGA-F4-6570	COAD	TCGA	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.1111
p.P515L	TCGA-F4-6570	COAD	TCGA	VPTPATT	DEG_SCF_FBW7_1	504:510	Mutation rewiring degron network	0.1944
p.P513T	TCGA-IR-A3LA	CESC	TCGA	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.1667
p.P513T	TCGA-IR-A3LA	CESC	TCGA	VPTPATT	DEG_SCF_FBW7_1	504:510	Mutation rewiring degron network	0.25
p.A507V	DO233649	GACA	ICGC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation altering degron motif	0.6936
p.A507V	DO233649	GACA	ICGC	VPTPATT	DEG_SCF_FBW7_1	504:510	Mutation altering degron motif	0.6936
p.R515C	DO233918	GACA	ICGC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.1111
p.R515C	DO233918	GACA	ICGC	VPTPATT	DEG_SCF_FBW7_1	504:510	Mutation rewiring degron network	0.1944
p.R493H	DO13635	GBM	ICGC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.25
p.A508S	DO229045	LICA	ICGC	VPTPATT	DEG_SCF_FBW7_1	504:510	Mutation altering degron motif	0.6477
p.P487S	DO52231	LIHC	ICGC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.0833
p.P487L	DO38123	SKCM	ICGC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.0833
p.A489V	DO38404	STAD	ICGC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.1389
p.E489D	DO229227	THCA	ICGC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.1389
p.S491L	DO41572	UCEC	ICGC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.1944
p.S501C	SIDM01042	Breast Carcinoma	GDSC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation altering degron motif	0.7541
p.S501C	ACH-001065	Breast Cancer	CCLE	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation altering degron motif	0.7541
p.S501C	EVSA-T	breast	COSMIC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation altering degron motif	0.7541
p.T502I	SIDM01609	Endometrial Carcinoma	GDSC	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation altering degron motif	0.5966
p.T502I	ACH-000972	Endometrial/Uterine Cancer	CCLE	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation altering degron motif	0.5966
p.P500L	ACH-000173	Endometrial/Uterine Cancer	CCLE	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation altering degron motif	0.6471
p.P517A	ACH-000988	Endometrial/Uterine Cancer	CCLE	SEELPSTAVPTP	DEG_COP1_1	496:507	Mutation rewiring degron network	0.0556
p.P517A	ACH-000988	Endometrial/Uterine Cancer	CCLE	VPTPATT	DEG_SCF_FBW7_1	504:510	Mutation rewiring degron network	0.1389

Kaplan plot for SH3BP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3BP1

UniProt ID: Q9Y3L3

Entrez ID: 23616

Protein name: SH3 domain-binding protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3BP1 in