DegronMD

Uniprot ID: Q9Y3L3

Source protein: SH3 domain-binding protein 1

Source gene: SH3BP1

Class: DEG_SCF_FBW7_1

Location: 504:510

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 90.6714

COIL: 0.9759

CONS_SCORE: 0.391

DSS_SCORE: 0.6681

HELIX: 0.0104

FCONS_SCORE: 1.2202

RIG_SCORE: 0.6179

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A507V	DO233649	GACA	ICGC	VPTPATT	DEG_SCF_FBW7_1	0.6936
p.A508S	DO229045	LICA	ICGC	VPTPATT	DEG_SCF_FBW7_1	0.6477
p.P513T	TCGA-IR-A3LA	CESC	TCGA	VPTPATT	DEG_SCF_FBW7_1	0.25
p.P515L	TCGA-F4-6570	COAD	TCGA	VPTPATT	DEG_SCF_FBW7_1	0.1944
p.R515C	DO233918	GACA	ICGC	VPTPATT	DEG_SCF_FBW7_1	0.1944
p.P517A	ACH-000988	Endometrial/Uterine Cancer	CCLE	VPTPATT	DEG_SCF_FBW7_1	0.1389

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3L3	SH3 domain-binding protein 1	DEG_SCF_FBW7_1	504:510	VPTPATT	FBXW7	0.9958	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons