DegronMD

Uniprot ID: P49418

Source protein: Amphiphysin

Source gene: AMPH

Class: DEG_COP1_1

Location: 322:332

E3 ligase: COP1

DEGRON score: 0.8681

ASA_SCORE: 96.7909

COIL: 0.7801

CONS_SCORE: 0.3332

DSS_SCORE: 0.4283

HELIX: 0.1499

FCONS_SCORE: 1.0189

RIG_SCORE: 0.8101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q317K	TCGA-05-4382	LUAD	TCGA	SFFEDNFVPEI	DEG_COP1_1	0.1944
p.Q317K	DO24900	LUAD	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.1944
p.P330L	TCGA-A6-5667	COAD	TCGA	SFFEDNFVPEI	DEG_COP1_1	0.7582
p.P330L	DO9868	COAD	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.7582
p.E331Q	TCGA-EK-A3GK	CESC	TCGA	SFFEDNFVPEI	DEG_COP1_1	0.6744
p.E331Q	DO49964	CESC	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.6744
p.E325K	TCGA-G2-A3IB	BLCA	TCGA	SFFEDNFVPEI	DEG_COP1_1	0.7022
p.E325K	DO512	BLCA	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.7022
p.E325K	SIDM00773	Non-Cancerous	GDSC	SFFEDNFVPEI	DEG_COP1_1	0.7022
p.E325K	SIDM00855	Other Sarcomas	GDSC	SFFEDNFVPEI	DEG_COP1_1	0.7022
p.E325K	SIDM00774	Breast Carcinoma	GDSC	SFFEDNFVPEI	DEG_COP1_1	0.7022
p.I320N	TCGA-G3-AAV3	LIHC	TCGA	SFFEDNFVPEI	DEG_COP1_1	0.2778
p.I320N	DO52297	LIHC	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.2778
p.V329F	TCGA-UB-A7MB	LIHC	TCGA	SFFEDNFVPEI	DEG_COP1_1	0.7068
p.V329F	DO52318	LIHC	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.7068
p.V329F	DO229213	THCA	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.7068
p.E331K	DO233147	GACA	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.7022
p.P330T	DO231983	LICA	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.7031
p.P330S	DO222843	MELA	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.6752
p.P330A	DO46538	OV	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.7503
p.E318D	DO33037	PACA	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.2222
p.F328L	DO229221	THCA	ICGC	SFFEDNFVPEI	DEG_COP1_1	0.587
p.S333N	SIDM00845	Burkitt's Lymphoma	GDSC	SFFEDNFVPEI	DEG_COP1_1	0.3056
p.E325D	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	SFFEDNFVPEI	DEG_COP1_1	0.5647
p.E325D	ACH-001642	Lymphoma	CCLE	SFFEDNFVPEI	DEG_COP1_1	0.5647
p.E325D	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	SFFEDNFVPEI	DEG_COP1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49418	Amphiphysin	DEG_COP1_1	322:332	SFFEDNFVPEI	COP1	0.8681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SFFEDNFVPEI

Degron related mutations and impact score

Drug responses associated with AMPH mutations

All proteins holding degron of SFFEDNFVPEI