DegronMD

Uniprot ID: Q9H6A9

Source protein: Pecanex-like protein 3

Source gene: PCNX3

Class: DEG_SCF_SKP2-CKS1_1

Location: 287:294

E3 ligase: SKP2,CSK1

DEGRON score: 0.7569

ASA_SCORE: 92.7

COIL: 0.9243

CONS_SCORE: 0.3378

DSS_SCORE: 0.7547

HELIX: 0.0345

FCONS_SCORE: 0.9166

RIG_SCORE: 0.5471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D283N	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SGEPTPQK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D283N	SIDM00773	Non-Cancerous	GDSC	SGEPTPQK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D283N	SIDM00721	Small Cell Lung Carcinoma	GDSC	SGEPTPQK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D283N	SIDM00774	Breast Carcinoma	GDSC	SGEPTPQK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T291M	SIDM00014	Colorectal Carcinoma	GDSC	SGEPTPQK	DEG_SCF_SKP2-CKS1_1	0.8534
p.T291M	LIM1215	large_intestine	COSMIC	SGEPTPQK	DEG_SCF_SKP2-CKS1_1	0.8534

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H6A9	Pecanex-like protein 3	DEG_SCF_SKP2-CKS1_1	287:294	SGEPTPQK	SKP2,CSK1	0.7569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons