DegronMD

Uniprot ID: O94913

Source protein: Pre-mRNA cleavage complex 2 protein Pcf11

Source gene: PCF11

Class: DEG_COP1_1

Location: 184:194

E3 ligase: COP1

DEGRON score: 0.9853

ASA_SCORE: 90.3818

COIL: 0.9187

CONS_SCORE: 0.32

DSS_SCORE: 0.4974

HELIX: 0.0662

FCONS_SCORE: 0.9539

RIG_SCORE: 0.6928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K196N	TCGA-AA-A010	COAD	TCGA	SISTPPIVPDI	DEG_COP1_1	0.7222
p.K196N	TCGA-AP-A056	UCEC	TCGA	SISTPPIVPDI	DEG_COP1_1	0.7222
p.K196N	DO222884	COCA	ICGC	SISTPPIVPDI	DEG_COP1_1	0.7222
p.K196N	DO43971	UCEC	ICGC	SISTPPIVPDI	DEG_COP1_1	0.7222
p.Q202H	TCGA-AP-A1DP	UCEC	TCGA	SISTPPIVPDI	DEG_COP1_1	0.1111
p.Q202H	DO42336	UCEC	ICGC	SISTPPIVPDI	DEG_COP1_1	0.1111
p.P188L	TCGA-BQ-7050	KIRP	TCGA	SISTPPIVPDI	DEG_COP1_1	0.6471
p.P188L	DO20877	KIRP	ICGC	SISTPPIVPDI	DEG_COP1_1	0.6471
p.P188L	SIDM01078	Small Cell Lung Carcinoma	GDSC	SISTPPIVPDI	DEG_COP1_1	0.6471
p.P188L	ACH-000790	Lung Cancer	CCLE	SISTPPIVPDI	DEG_COP1_1	0.6471
p.P188L	SHP-77	lung	COSMIC	SISTPPIVPDI	DEG_COP1_1	0.6471
p.P192H	TCGA-CV-7100	HNSC	TCGA	SISTPPIVPDI	DEG_COP1_1	0.7694
p.P192H	DO15503	HNSC	ICGC	SISTPPIVPDI	DEG_COP1_1	0.7694
p.L198F	TCGA-DU-6407	LGG	TCGA	SISTPPIVPDI	DEG_COP1_1	0.2222
p.L198F	DO22295	LGG	ICGC	SISTPPIVPDI	DEG_COP1_1	0.2222
p.I190V	SIDM00694	Other Solid Cancers	GDSC	SISTPPIVPDI	DEG_COP1_1	0.5965
p.I190V	SIDM01664	Prostate Carcinoma	GDSC	SISTPPIVPDI	DEG_COP1_1	0.5965
p.Q195H	SIDM01588	Endometrial Carcinoma	GDSC	SISTPPIVPDI	DEG_COP1_1	0.3056
p.Q195H	ACH-000993	Endometrial/Uterine Cancer	CCLE	SISTPPIVPDI	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94913	Pre-mRNA cleavage complex 2 protein Pcf11	DEG_COP1_1	184:194	SISTPPIVPDI	COP1	0.9853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons