DegronMD

Uniprot ID: Q86SU0

Source protein: Immunoglobulin-like domain-containing receptor 1

Source gene: ILDR1

Class: DEG_SCF_SKP2-CKS1_1

Location: 514:521

E3 ligase: SKP2,CSK1

DEGRON score: 0.9015

ASA_SCORE: 86.4375

COIL: 0.889

CONS_SCORE: 0.6077

DSS_SCORE: 0.6868

HELIX: 0.0756

FCONS_SCORE: 1.0496

RIG_SCORE: 0.6331

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K525E	TCGA-AA-3811	COAD	TCGA	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.3333
p.K508R	SIDM01120	Other Solid Cancers	GDSC	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K508R	ACH-002174	Lung Cancer	CCLE	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K508R	NCI-H720	lung	COSMIC	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.E506K	SIDM00353	Other Sarcomas	GDSC	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E506K	SIDM00767	Small Cell Lung Carcinoma	GDSC	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E506K	RKN	ovary	COSMIC	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.E506K	NCI-H187	lung	COSMIC	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.S505R	DO229045	LICA	ICGC	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.D504Y	DO36556	READ	ICGC	SLDITPGK	DEG_SCF_SKP2-CKS1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SU0	Immunoglobulin-like domain-containing receptor 1	DEG_SCF_SKP2-CKS1_1	514:521	SLDITPGK	SKP2,CSK1	0.9015	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons