DegronMD

Uniprot ID: Q5SQQ9

Source protein: Ventral anterior homeobox 1

Source gene: VAX1

Class: DEG_COP1_1

Location: 271:280

E3 ligase: COP1

DEGRON score: 0.8234

ASA_SCORE: 46.76

COIL: 0.7663

CONS_SCORE: 0.491

DSS_SCORE: 0.2342

HELIX: 0.1432

FCONS_SCORE: 1.2783

RIG_SCORE: 0.7475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L281R	TCGA-L5-A43E	ESCA	TCGA	SLFSLPVPSL	DEG_COP1_1	0.3056
p.R287S	TCGA-OR-A5KB	ACC	TCGA	SLFSLPVPSL	DEG_COP1_1	0.1389
p.S283A	DO50349	ESAD	ICGC	SLFSLPVPSL	DEG_COP1_1	0.25
p.P266L	DO233749	GACA	ICGC	SLFSLPVPSL	DEG_COP1_1	0.1944
p.L272I	DO229028	LICA	ICGC	SLFSLPVPSL	DEG_COP1_1	0.6063
p.A265S	SIDM02021	Esophageal Carcinoma	GDSC	SLFSLPVPSL	DEG_COP1_1	0.1667
p.A265T	SIDM00447	B-Lymphoblastic Leukemia	GDSC	SLFSLPVPSL	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SQQ9	Ventral anterior homeobox 1	DEG_COP1_1	271:280	SLFSLPVPSL	COP1	0.8234	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons