DegronMD

Uniprot ID: Q8N149

Source protein: Leukocyte immunoglobulin-like receptor subfamily A member 2

Source gene: LILRA2

Class: DEG_COP1_1

Location: 325:334

E3 ligase: COP1

DEGRON score: 0.9562

ASA_SCORE: 51.17

COIL: 0.7661

CONS_SCORE: 0.5429

DSS_SCORE: 0.3461

HELIX: 0.0699

FCONS_SCORE: 1.1135

RIG_SCORE: 0.7351

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L326I	TCGA-55-A4DG	LUAD	TCGA	SLSVQPVPTV	DEG_COP1_1	0.6063
p.L326I	DO26337	LUAD	ICGC	SLSVQPVPTV	DEG_COP1_1	0.6063
p.P332H	TCGA-78-7540	LUAD	TCGA	SLSVQPVPTV	DEG_COP1_1	0.7694
p.P332H	DO23810	LUAD	ICGC	SLSVQPVPTV	DEG_COP1_1	0.7694
p.T341I	TCGA-90-A4ED	LUSC	TCGA	SLSVQPVPTV	DEG_COP1_1	0.1389
p.T341I	DO45482	LUSC	ICGC	SLSVQPVPTV	DEG_COP1_1	0.1389
p.T341A	TCGA-A5-A0G2	UCEC	TCGA	SLSVQPVPTV	DEG_COP1_1	0.1389
p.T341A	DO41235	UCEC	ICGC	SLSVQPVPTV	DEG_COP1_1	0.1389
p.K338R	TCGA-B5-A5OC	UCEC	TCGA	SLSVQPVPTV	DEG_COP1_1	0.3333
p.K338R	DO52405	UCEC	ICGC	SLSVQPVPTV	DEG_COP1_1	0.3333
p.R323K	TCGA-BF-A1PV	SKCM	TCGA	SLSVQPVPTV	DEG_COP1_1	0.2778
p.R323K	TCGA-DA-A1IC	SKCM	TCGA	SLSVQPVPTV	DEG_COP1_1	0.2778
p.R323K	DO37430	SKCM	ICGC	SLSVQPVPTV	DEG_COP1_1	0.2778
p.R323K	DO47309	SKCM	ICGC	SLSVQPVPTV	DEG_COP1_1	0.2778
p.I316T	TCGA-CN-A49A	HNSC	TCGA	SLSVQPVPTV	DEG_COP1_1	0.0833
p.I316T	DO52042	HNSC	ICGC	SLSVQPVPTV	DEG_COP1_1	0.0833
p.P332S	TCGA-CN-A63U	HNSC	TCGA	SLSVQPVPTV	DEG_COP1_1	0.6752
p.P332S	DO44454	HNSC	ICGC	SLSVQPVPTV	DEG_COP1_1	0.6752
p.G337E	TCGA-D3-A3MU	SKCM	TCGA	SLSVQPVPTV	DEG_COP1_1	0.25
p.G337E	TCGA-EB-A3Y7	SKCM	TCGA	SLSVQPVPTV	DEG_COP1_1	0.25
p.G337E	DO37499	SKCM	ICGC	SLSVQPVPTV	DEG_COP1_1	0.25
p.G337E	DO47337	SKCM	ICGC	SLSVQPVPTV	DEG_COP1_1	0.25
p.T333A	TCGA-ZS-A9CD	LIHC	TCGA	SLSVQPVPTV	DEG_COP1_1	0.7139
p.T333A	DO52334	LIHC	ICGC	SLSVQPVPTV	DEG_COP1_1	0.7139
p.L342R	DO44832	LICA	ICGC	SLSVQPVPTV	DEG_COP1_1	0.1111
p.S327L	DO228376	MALY	ICGC	SLSVQPVPTV	DEG_COP1_1	0.7667
p.T317A	SIDM00617	Hepatocellular Carcinoma	GDSC	SLSVQPVPTV	DEG_COP1_1	0.1111
p.T317A	JHH-2	liver	COSMIC	SLSVQPVPTV	DEG_COP1_1	0.1111
p.P336S	SIDM00352	Ovarian Carcinoma	GDSC	SLSVQPVPTV	DEG_COP1_1	0.2778
p.P336S	SIDM00281	Other Solid Cancers	GDSC	SLSVQPVPTV	DEG_COP1_1	0.2778
p.P336S	DJM-1	skin	COSMIC	SLSVQPVPTV	DEG_COP1_1	0.2778
p.P336S	RMG-I	ovary	COSMIC	SLSVQPVPTV	DEG_COP1_1	0.2778
p.A335S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SLSVQPVPTV	DEG_COP1_1	0.3056
p.A335S	EMC-BAC-1	lung	COSMIC	SLSVQPVPTV	DEG_COP1_1	0.3056
p.P324S	ACH-000719	Ovarian Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	0.3056
p.P324S	ACH-002100	Skin Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	0.3056
p.P324S	RMG-I	ovary	COSMIC	SLSVQPVPTV	DEG_COP1_1	0.3056
p.P324S	DJM-1	skin	COSMIC	SLSVQPVPTV	DEG_COP1_1	0.3056
p.R335W	ACH-000797	Non-Cancerous	CCLE	SLSVQPVPTV	DEG_COP1_1	0.3056
p.Q337H	ACH-000868	Lung Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	0.25
p.R323T	ACH-000870	Lung Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	0.2778
p.A323S	ACH-002101	Lung Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	0.2778
p.A323S	EMC-BAC-1	lung	COSMIC	SLSVQPVPTV	DEG_COP1_1	0.2778
p.R335Q	ACH-002113	Bone Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	0.3056
p.R335Q	EW-13	bone	COSMIC	SLSVQPVPTV	DEG_COP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SLSVQPVPTV

Degron related mutations and impact score

Drug responses associated with LILRA2 mutations

All proteins holding degron of SLSVQPVPTV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N149	Leukocyte immunoglobulin-like receptor subfamily A member 2	DEG_COP1_1	325:334	SLSVQPVPTV	COP1	0.9562	More...