DegronMD - Q8N149(LILRA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G12R	TCGA-39-5036	LUSC	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.1667
p.G12R	DO27508	LUSC	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.1667
p.G12R	SIDM00944	Colorectal Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.1667
p.G12R	CL-11	large intestine	COSMIC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.1667
p.L326I	TCGA-55-A4DG	LUAD	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.6063
p.L326I	DO26337	LUAD	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.6063
p.T6M	TCGA-59-2349	OV	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T6M	TCGA-CN-5358	HNSC	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T6M	TCGA-EM-A22J	THCA	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T6M	DO229016	COCA	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T6M	DO14878	HNSC	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T6M	DO28621	OV	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T6M	DO39096	THCA	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T6M	SIDM00807	Bladder Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.T6M	SIDM01131	Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7423
p.P332H	TCGA-78-7540	LUAD	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.7694
p.P332H	DO23810	LUAD	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.7694
p.T341I	TCGA-90-A4ED	LUSC	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1389
p.T341I	DO45482	LUSC	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1389
p.T341A	TCGA-A5-A0G2	UCEC	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1389
p.T341A	DO41235	UCEC	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1389
p.V7I	TCGA-AB-2833	LAML	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.3056
p.V7I	DO21679	LAML	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.3056
p.K338R	TCGA-B5-A5OC	UCEC	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation substituting flanking lysine	0.3333
p.K338R	DO52405	UCEC	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation substituting flanking lysine	0.3333
p.R323K	TCGA-BF-A1PV	SKCM	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.R323K	TCGA-DA-A1IC	SKCM	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.R323K	DO37430	SKCM	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.R323K	DO47309	SKCM	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.G16D	TCGA-BT-A20P	BLCA	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.G16D	DO675	BLCA	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0556
p.P3L	TCGA-BW-A5NO	LIHC	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7582
p.P3L	DO52171	LIHC	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7582
p.I316T	TCGA-CN-A49A	HNSC	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.0833
p.I316T	DO52042	HNSC	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.0833
p.P332S	TCGA-CN-A63U	HNSC	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.6752
p.P332S	DO44454	HNSC	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.6752
p.G337E	TCGA-D3-A3MU	SKCM	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.25
p.G337E	TCGA-EB-A3Y7	SKCM	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.25
p.G337E	DO37499	SKCM	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.25
p.G337E	DO47337	SKCM	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.25
p.S14R	TCGA-D9-A1JX	SKCM	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.1111
p.S14R	DO37711	SKCM	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.1111
p.L15P	TCGA-EO-A22R	UCEC	TCGA	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.L15P	DO42713	UCEC	ICGC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.0833
p.T333A	TCGA-ZS-A9CD	LIHC	TCGA	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.7139
p.T333A	DO52334	LIHC	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.7139
p.L342R	DO44832	LICA	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1111
p.S327L	DO228376	MALY	ICGC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation altering degron motif	0.7667
p.P3H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7694
p.P3H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7694
p.T317A	SIDM00617	Hepatocellular Carcinoma	GDSC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1111
p.T317A	JHH-2	liver	COSMIC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.1111
p.P3T	SIDM00698	Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7031
p.P3T	ACH-000506	Lung Cancer	CCLE	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7031
p.P3T	NCI-H146	lung	COSMIC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation altering degron motif	0.7031
p.P336S	SIDM00352	Ovarian Carcinoma	GDSC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.P336S	SIDM00281	Other Solid Cancers	GDSC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.P336S	DJM-1	skin	COSMIC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.P336S	RMG-I	ovary	COSMIC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.C10R	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.2222
p.C10R	ACH-001233	Lung Cancer	CCLE	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.2222
p.C10R	VMRC-LCD	lung	COSMIC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.2222
p.A335S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.A335S	EMC-BAC-1	lung	COSMIC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.C10G	SIDM01613	Colorectal Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.2222
p.P324S	ACH-000719	Ovarian Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.P324S	ACH-002100	Skin Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.P324S	RMG-I	ovary	COSMIC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.P324S	DJM-1	skin	COSMIC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.R335W	ACH-000797	Non-Cancerous	CCLE	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.Q337H	ACH-000868	Lung Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.25
p.R323T	ACH-000870	Lung Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.A323S	ACH-002101	Lung Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.A323S	EMC-BAC-1	lung	COSMIC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.2778
p.R335Q	ACH-002113	Bone Cancer	CCLE	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.R335Q	EW-13	bone	COSMIC	SLSVQPVPTV	DEG_COP1_1	325:334	Mutation rewiring degron network	0.3056
p.H13P	DIFI	large intestine	COSMIC	MTPILT	DEG_SCF_FBW7_1	1:6	Mutation rewiring degron network	0.1389

Kaplan plot for LILRA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LILRA2

UniProt ID: Q8N149

Entrez ID: 11027

Protein name: Leukocyte immunoglobulin-like receptor subfamily A member 2 (CD85 antigen-like family member H) (Immunoglobulin-like transcript 1) (ILT-1) (Leukocyte immunoglobulin-like receptor 7) (LIR-7) (CD antigen CD85h)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LILRA2 in