DegronMD

Uniprot ID: Q8N149

Source protein: Leukocyte immunoglobulin-like receptor subfamily A member 2

Source gene: LILRA2

Class: DEG_SCF_FBW7_1

Location: 1:6

E3 ligase: FBXW7

DEGRON score: 0.5949

ASA_SCORE: 55.7833

COIL: 0.4595

CONS_SCORE: 0.5715

DSS_SCORE: 0.3701

HELIX: 0.505

FCONS_SCORE: 1.0464

RIG_SCORE: 0.8959

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G12R	TCGA-39-5036	LUSC	TCGA	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12R	DO27508	LUSC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12R	SIDM00944	Colorectal Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12R	CL-11	large_intestine	COSMIC	MTPILT	DEG_SCF_FBW7_1	0.1667
p.T6M	TCGA-59-2349	OV	TCGA	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	TCGA-CN-5358	HNSC	TCGA	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	TCGA-EM-A22J	THCA	TCGA	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO229016	COCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO14878	HNSC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO28621	OV	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO39096	THCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	SIDM00807	Bladder Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	SIDM01131	Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.V7I	TCGA-AB-2833	LAML	TCGA	MTPILT	DEG_SCF_FBW7_1	0.3056
p.V7I	DO21679	LAML	ICGC	MTPILT	DEG_SCF_FBW7_1	0.3056
p.G16D	TCGA-BT-A20P	BLCA	TCGA	MTPILT	DEG_SCF_FBW7_1	0.0556
p.G16D	DO675	BLCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.0556
p.P3L	TCGA-BW-A5NO	LIHC	TCGA	MTPILT	DEG_SCF_FBW7_1	0.7582
p.P3L	DO52171	LIHC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7582
p.S14R	TCGA-D9-A1JX	SKCM	TCGA	MTPILT	DEG_SCF_FBW7_1	0.1111
p.S14R	DO37711	SKCM	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1111
p.L15P	TCGA-EO-A22R	UCEC	TCGA	MTPILT	DEG_SCF_FBW7_1	0.0833
p.L15P	DO42713	UCEC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.0833
p.P3H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MTPILT	DEG_SCF_FBW7_1	0.7694
p.P3H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MTPILT	DEG_SCF_FBW7_1	0.7694
p.P3T	SIDM00698	Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.7031
p.P3T	ACH-000506	Lung Cancer	CCLE	MTPILT	DEG_SCF_FBW7_1	0.7031
p.P3T	NCI-H146	lung	COSMIC	MTPILT	DEG_SCF_FBW7_1	0.7031
p.C10R	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.2222
p.C10R	ACH-001233	Lung Cancer	CCLE	MTPILT	DEG_SCF_FBW7_1	0.2222
p.C10R	VMRC-LCD	lung	COSMIC	MTPILT	DEG_SCF_FBW7_1	0.2222
p.C10G	SIDM01613	Colorectal Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.2222
p.H13P	DIFI	large_intestine	COSMIC	MTPILT	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPILT

Degron related mutations and impact score

Drug responses associated with LILRA2 mutations

All proteins holding degron of MTPILT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N149	Leukocyte immunoglobulin-like receptor subfamily A member 2	DEG_SCF_FBW7_1	1:6	MTPILT	FBXW7	0.5949	More...
Q8N6C8	Leukocyte immunoglobulin-like receptor subfamily A member 3	DEG_SCF_FBW7_1	1:6	MTPILT	FBXW7	0.5163	More...