DegronMD

Uniprot ID: Q8N149

Source protein: Leukocyte immunoglobulin-like receptor subfamily A member 2

Source gene: LILRA2

Class: DEG_SCF_FBW7_1

Location: 1:6

E3 ligase: FBXW7

DEGRON score: 0.5949

ASA_SCORE: 55.7833

COIL: 0.4595

CONS_SCORE: 0.5715

DSS_SCORE: 0.3701

HELIX: 0.505

FCONS_SCORE: 1.0464

RIG_SCORE: 0.8959

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MTPILT	DEG_SCF_FBW7_1	0.7694
p.P3H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MTPILT	DEG_SCF_FBW7_1	0.7694
p.P3L	TCGA-BW-A5NO	LIHC	TCGA	MTPILT	DEG_SCF_FBW7_1	0.7582
p.P3L	DO52171	LIHC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7582
p.T6M	TCGA-59-2349	OV	TCGA	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	TCGA-CN-5358	HNSC	TCGA	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	TCGA-EM-A22J	THCA	TCGA	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO229016	COCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO14878	HNSC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO28621	OV	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO39096	THCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	SIDM00807	Bladder Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	SIDM01131	Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.P3T	SIDM00698	Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.7031
p.P3T	ACH-000506	Lung Cancer	CCLE	MTPILT	DEG_SCF_FBW7_1	0.7031
p.P3T	NCI-H146	lung	COSMIC	MTPILT	DEG_SCF_FBW7_1	0.7031
p.V7I	TCGA-AB-2833	LAML	TCGA	MTPILT	DEG_SCF_FBW7_1	0.3056
p.V7I	DO21679	LAML	ICGC	MTPILT	DEG_SCF_FBW7_1	0.3056
p.C10R	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.2222
p.C10R	ACH-001233	Lung Cancer	CCLE	MTPILT	DEG_SCF_FBW7_1	0.2222
p.C10R	VMRC-LCD	lung	COSMIC	MTPILT	DEG_SCF_FBW7_1	0.2222
p.C10G	SIDM01613	Colorectal Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.2222
p.G12R	TCGA-39-5036	LUSC	TCGA	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12R	DO27508	LUSC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12R	SIDM00944	Colorectal Carcinoma	GDSC	MTPILT	DEG_SCF_FBW7_1	0.1667

Showing 1 to 25 of 33 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N149	Leukocyte immunoglobulin-like receptor subfamily A member 2	DEG_SCF_FBW7_1	1:6	MTPILT	FBXW7	0.5949	More...
Q8N6C8	Leukocyte immunoglobulin-like receptor subfamily A member 3	DEG_SCF_FBW7_1	1:6	MTPILT	FBXW7	0.5163	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons