DegronMD

Uniprot ID: Q8N6C8

Source protein: Leukocyte immunoglobulin-like receptor subfamily A member 3

Source gene: LILRA3

Class: DEG_SCF_FBW7_1

Location: 1:6

E3 ligase: FBXW7

DEGRON score: 0.5163

ASA_SCORE: 56.3333

COIL: 0.462

CONS_SCORE: 0.555

DSS_SCORE: 0.4044

HELIX: 0.4958

FCONS_SCORE: 1.0021

RIG_SCORE: 0.8862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G12V	TCGA-97-8172	LUAD	TCGA	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12V	DO26384	LUAD	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1667
p.D16G	TCGA-EI-6917	READ	TCGA	MTPILT	DEG_SCF_FBW7_1	0.0556
p.D16G	DO36881	READ	ICGC	MTPILT	DEG_SCF_FBW7_1	0.0556
p.D16G	ACH-000738	Brain Cancer	CCLE	MTPILT	DEG_SCF_FBW7_1	0.0556
p.L11I	TCGA-EO-A22R	UCEC	TCGA	MTPILT	DEG_SCF_FBW7_1	0.1944
p.L11I	DO42713	UCEC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1944
p.G12R	TCGA-YL-A9WK	PRAD	TCGA	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12R	DO225216	BRCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12R	DO227480	BRCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G12R	DO51443	PRAD	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1667
p.G15V	DO51893	BLCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.0833
p.T6M	DO224640	BRCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.T6M	DO52538	BRCA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.7423
p.L5F	DO10276	COAD	ICGC	MTPILT	DEG_SCF_FBW7_1	0.587
p.L5F	DO43041	UCEC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.587
p.P3S	DO231075	LUSC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.6752
p.S14N	DO222880	MELA	ICGC	MTPILT	DEG_SCF_FBW7_1	0.1111
p.S10I	DO42713	UCEC	ICGC	MTPILT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N149	Leukocyte immunoglobulin-like receptor subfamily A member 2	DEG_SCF_FBW7_1	1:6	MTPILT	FBXW7	0.5949	More...
Q8N6C8	Leukocyte immunoglobulin-like receptor subfamily A member 3	DEG_SCF_FBW7_1	1:6	MTPILT	FBXW7	0.5163	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons