DegronMD

Uniprot ID: Q9NZC9

Source protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

Source gene: SMARCAL1

Class: DEG_COP1_1

Location: 415:423

E3 ligase: COP1

DEGRON score: 0.5283

ASA_SCORE: 78.8778

COIL: 0.7569

CONS_SCORE: 0.3229

DSS_SCORE: 0.368

HELIX: 0.2192

FCONS_SCORE: 0.8419

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K411N	TCGA-43-6770	LUSC	TCGA	SLTPDVPEA	DEG_COP1_1	0.6667
p.K411N	DO27644	LUSC	ICGC	SLTPDVPEA	DEG_COP1_1	0.6667
p.E427K	TCGA-P3-A5QF	HNSC	TCGA	SLTPDVPEA	DEG_COP1_1	0.2222
p.E427K	DO44439	HNSC	ICGC	SLTPDVPEA	DEG_COP1_1	0.2222
p.V420F	DO229029	LICA	ICGC	SLTPDVPEA	DEG_COP1_1	0.7068
p.V433M	SIDM01020	Plasma Cell Myeloma	GDSC	SLTPDVPEA	DEG_COP1_1	0.0556
p.V433M	SIDM01617	Endometrial Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.0556
p.V433M	ACH-000380	Myeloma	CCLE	SLTPDVPEA	DEG_COP1_1	0.0556
p.V433M	ACH-000994	Endometrial/Uterine Cancer	CCLE	SLTPDVPEA	DEG_COP1_1	0.0556
p.V433M	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	SLTPDVPEA	DEG_COP1_1	0.0556
p.L432V	SIDM00884	Breast Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.0833
p.L432V	ACH-000699	Breast Cancer	CCLE	SLTPDVPEA	DEG_COP1_1	0.0833
p.L432V	HCC1395	breast	COSMIC	SLTPDVPEA	DEG_COP1_1	0.0833
p.D424V	SIDM00987	Thyroid Gland Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.3056
p.D424V	SIDM00227	Neuroblastoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.3056
p.D424V	SIDM00657	Acute Myeloid Leukemia	GDSC	SLTPDVPEA	DEG_COP1_1	0.3056
p.D424V	SIDM00259	Neuroblastoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.3056
p.D424V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.3056
p.D424V	SIDM01765	Osteosarcoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.3056
p.S415G	SIDM01021	Glioblastoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.6993
p.V420A	SIDM00163	Biliary Tract Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	0.6936
p.K431Q	ACH-002023	Colon/Colorectal Cancer	CCLE	SLTPDVPEA	DEG_COP1_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZC9	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1	DEG_COP1_1	415:423	SLTPDVPEA	COP1	0.5283	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons