DegronMD - Q9NZC9(SMARCAL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K411N	TCGA-43-6770	LUSC	TCGA	SLTPDVPEA	DEG_COP1_1	415:423	Mutation blocking ubiquitination signal	0.6667
p.K411N	DO27644	LUSC	ICGC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation blocking ubiquitination signal	0.6667
p.S205Y	TCGA-AA-A010	COAD	TCGA	VTPRTE	DEG_SCF_FBW7_2	214:219	Mutation rewiring degron network	0.0833
p.S213T	TCGA-BP-4963	KIRC	TCGA	VTPRTE	DEG_SCF_FBW7_2	214:219	Mutation rewiring degron network	0.3056
p.S213T	DO20653	KIRC	ICGC	VTPRTE	DEG_SCF_FBW7_2	214:219	Mutation rewiring degron network	0.3056
p.E427K	TCGA-P3-A5QF	HNSC	TCGA	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.2222
p.E427K	DO44439	HNSC	ICGC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.2222
p.V420F	DO229029	LICA	ICGC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation altering degron motif	0.7068
p.R221I	DO50817	LIRI	ICGC	VTPRTE	DEG_SCF_FBW7_2	214:219	Mutation rewiring degron network	0.2778
p.V433M	SIDM01020	Plasma Cell Myeloma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.0556
p.V433M	SIDM01617	Endometrial Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.0556
p.V433M	ACH-000380	Myeloma	CCLE	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.0556
p.V433M	ACH-000994	Endometrial/Uterine Cancer	CCLE	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.0556
p.V433M	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.0556
p.L432V	SIDM00884	Breast Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.0833
p.L432V	ACH-000699	Breast Cancer	CCLE	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.0833
p.L432V	HCC1395	breast	COSMIC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.0833
p.D424V	SIDM00987	Thyroid Gland Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.3056
p.D424V	SIDM00227	Neuroblastoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.3056
p.D424V	SIDM00657	Acute Myeloid Leukemia	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.3056
p.D424V	SIDM00259	Neuroblastoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.3056
p.D424V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.3056
p.D424V	SIDM01765	Osteosarcoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation rewiring degron network	0.3056
p.S415G	SIDM01021	Glioblastoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation altering degron motif	0.6993
p.E219Q	SIDM00528	Breast Carcinoma	GDSC	VTPRTE	DEG_SCF_FBW7_2	214:219	Mutation altering degron motif	0.6744
p.E219Q	ACH-000934	Breast Cancer	CCLE	VTPRTE	DEG_SCF_FBW7_2	214:219	Mutation altering degron motif	0.6744
p.E219Q	MDA-MB-361	breast	COSMIC	VTPRTE	DEG_SCF_FBW7_2	214:219	Mutation altering degron motif	0.6744
p.V420A	SIDM00163	Biliary Tract Carcinoma	GDSC	SLTPDVPEA	DEG_COP1_1	415:423	Mutation altering degron motif	0.6936
p.K431Q	ACH-002023	Colon/Colorectal Cancer	CCLE	SLTPDVPEA	DEG_COP1_1	415:423	Mutation blocking ubiquitination signal	0.5556

Kaplan plot for SMARCAL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCAL1

UniProt ID: Q9NZC9

Entrez ID: 50485

Protein name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (hHARP) (Sucrose nonfermenting protein 2-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMARCAL1 in