DegronMD

Uniprot ID: Q9NZC9

Source protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

Source gene: SMARCAL1

Class: DEG_SCF_FBW7_2

Location: 214:219

E3 ligase: FBXW7

DEGRON score: 0.8509

ASA_SCORE: 92.9333

COIL: 0.9027

CONS_SCORE: 0.2921

DSS_SCORE: 0.6763

HELIX: 0.0363

FCONS_SCORE: 1.0262

RIG_SCORE: 0.6608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S205Y	TCGA-AA-A010	COAD	TCGA	VTPRTE	DEG_SCF_FBW7_2	0.0833
p.S213T	TCGA-BP-4963	KIRC	TCGA	VTPRTE	DEG_SCF_FBW7_2	0.3056
p.S213T	DO20653	KIRC	ICGC	VTPRTE	DEG_SCF_FBW7_2	0.3056
p.R221I	DO50817	LIRI	ICGC	VTPRTE	DEG_SCF_FBW7_2	0.2778
p.E219Q	SIDM00528	Breast Carcinoma	GDSC	VTPRTE	DEG_SCF_FBW7_2	0.6744
p.E219Q	ACH-000934	Breast Cancer	CCLE	VTPRTE	DEG_SCF_FBW7_2	0.6744
p.E219Q	MDA-MB-361	breast	COSMIC	VTPRTE	DEG_SCF_FBW7_2	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZC9	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1	DEG_SCF_FBW7_2	214:219	VTPRTE	FBXW7	0.8509	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons