DegronMD

Uniprot ID: Q5HYM0

Source protein: Probable ribonuclease ZC3H12B

Source gene: ZC3H12B

Class: DEG_COP1_1

Location: 464:474

E3 ligase: COP1

DEGRON score: 0.8234

ASA_SCORE: 84

COIL: 0.8041

CONS_SCORE: 0.4114

DSS_SCORE: 0.4239

HELIX: 0.1699

FCONS_SCORE: 1.0224

RIG_SCORE: 0.714

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G483R	TCGA-17-Z001	LUAD	TCGA	SLVTALSVPTI	DEG_COP1_1	0.0833
p.P475T	TCGA-21-5783	LUSC	TCGA	SLVTALSVPTI	DEG_COP1_1	0.3056
p.P475T	DO27437	LUSC	ICGC	SLVTALSVPTI	DEG_COP1_1	0.3056
p.P475T	SIDM00498	Colorectal Carcinoma	GDSC	SLVTALSVPTI	DEG_COP1_1	0.3056
p.P475T	ACH-000970	Colon/Colorectal Cancer	CCLE	SLVTALSVPTI	DEG_COP1_1	0.3056
p.P475T	SNU-C5	large_intestine	COSMIC	SLVTALSVPTI	DEG_COP1_1	0.3056
p.P463H	TCGA-46-3767	LUSC	TCGA	SLVTALSVPTI	DEG_COP1_1	0.3056
p.P463H	DO26650	LUSC	ICGC	SLVTALSVPTI	DEG_COP1_1	0.3056
p.G483C	TCGA-AJ-A2QO	UCEC	TCGA	SLVTALSVPTI	DEG_COP1_1	0.0833
p.G483C	DO42177	UCEC	ICGC	SLVTALSVPTI	DEG_COP1_1	0.0833
p.V471L	TCGA-BR-8361	STAD	TCGA	SLVTALSVPTI	DEG_COP1_1	0.6765
p.V471L	DO48032	STAD	ICGC	SLVTALSVPTI	DEG_COP1_1	0.6765
p.P472L	TCGA-D3-A2JF	SKCM	TCGA	SLVTALSVPTI	DEG_COP1_1	0.7582
p.P472L	DO38153	SKCM	ICGC	SLVTALSVPTI	DEG_COP1_1	0.7582
p.P457L	TCGA-DF-A2KU	UCEC	TCGA	SLVTALSVPTI	DEG_COP1_1	0.1389
p.P457L	DO223286	UCEC	ICGC	SLVTALSVPTI	DEG_COP1_1	0.1389
p.P463L	TCGA-EE-A3AC	SKCM	TCGA	SLVTALSVPTI	DEG_COP1_1	0.3056
p.P463L	DO37631	SKCM	ICGC	SLVTALSVPTI	DEG_COP1_1	0.3056
p.P457S	TCGA-FI-A2D5	UCEC	TCGA	SLVTALSVPTI	DEG_COP1_1	0.1389
p.P457S	DO41331	UCEC	ICGC	SLVTALSVPTI	DEG_COP1_1	0.1389
p.A454D	DO34192	PACA	ICGC	SLVTALSVPTI	DEG_COP1_1	0.0556
p.I474V	ACH-001451	Cervical Cancer	CCLE	SLVTALSVPTI	DEG_COP1_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYM0	Probable ribonuclease ZC3H12B	DEG_COP1_1	464:474	SLVTALSVPTI	COP1	0.8234	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons