DegronMD - Q5HYM0(ZC3H12B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E8D	TCGA-06-5416	GBM	TCGA	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation altering degron motif	0.5647
p.E8D	DO10880	GBM	ICGC	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation altering degron motif	0.5647
p.G483R	TCGA-17-Z001	LUAD	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.0833
p.P475T	TCGA-21-5783	LUSC	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.P475T	DO27437	LUSC	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.P475T	SIDM00498	Colorectal Carcinoma	GDSC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.P475T	ACH-000970	Colon/Colorectal Cancer	CCLE	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.P475T	SNU-C5	large intestine	COSMIC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.P463H	TCGA-46-3767	LUSC	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.P463H	DO26650	LUSC	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.G483C	TCGA-AJ-A2QO	UCEC	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.0833
p.G483C	DO42177	UCEC	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.0833
p.V471L	TCGA-BR-8361	STAD	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation altering degron motif	0.6765
p.V471L	DO48032	STAD	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation altering degron motif	0.6765
p.E20K	TCGA-BR-8591	STAD	TCGA	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation rewiring degron network	0.1389
p.E20K	DO47973	STAD	ICGC	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation rewiring degron network	0.1389
p.P472L	TCGA-D3-A2JF	SKCM	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation altering degron motif	0.7582
p.P472L	DO38153	SKCM	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation altering degron motif	0.7582
p.P457L	TCGA-DF-A2KU	UCEC	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.1389
p.P457L	DO223286	UCEC	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.1389
p.P463L	TCGA-EE-A3AC	SKCM	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.P463L	DO37631	SKCM	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.3056
p.P457S	TCGA-FI-A2D5	UCEC	TCGA	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.1389
p.P457S	DO41331	UCEC	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.1389
p.S17F	DO10843	ESAD	ICGC	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation blocking phosphorylation signal	0.6667
p.A5S	DO229008	LICA	ICGC	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation substituting flanking lysine	0.3889
p.A454D	DO34192	PACA	ICGC	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation rewiring degron network	0.0556
p.T2M	DO51112	PRAD	ICGC	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation blocking phosphorylation signal	0.6389
p.T2M	DO228760	PRAD	ICGC	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation blocking phosphorylation signal	0.6389
p.E13K	DO229494	SKCA	ICGC	VETPKME	DEG_SCF_FBW7_2	7:13	Mutation altering degron motif	0.7022
p.I474V	ACH-001451	Cervical Cancer	CCLE	SLVTALSVPTI	DEG_COP1_1	464:474	Mutation altering degron motif	0.5965

Kaplan plot for ZC3H12B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H12B

UniProt ID: Q5HYM0

Entrez ID: 340554

Protein name: Probable ribonuclease ZC3H12B (EC 3.1.-.-) (MCP-induced protein 2) (Zinc finger CCCH domain-containing protein 12B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H12B in