DegronMD

Uniprot ID: Q5HYM0

Source protein: Probable ribonuclease ZC3H12B

Source gene: ZC3H12B

Class: DEG_SCF_FBW7_2

Location: 7:13

E3 ligase: FBXW7

DEGRON score: 0.9593

ASA_SCORE: 99.6857

COIL: 0.7886

CONS_SCORE: 0.4283

DSS_SCORE: 0.7522

HELIX: 0.112

FCONS_SCORE: 1.0886

RIG_SCORE: 0.6916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E8D	TCGA-06-5416	GBM	TCGA	VETPKME	DEG_SCF_FBW7_2	0.5647
p.E8D	DO10880	GBM	ICGC	VETPKME	DEG_SCF_FBW7_2	0.5647
p.E20K	TCGA-BR-8591	STAD	TCGA	VETPKME	DEG_SCF_FBW7_2	0.1389
p.E20K	DO47973	STAD	ICGC	VETPKME	DEG_SCF_FBW7_2	0.1389
p.S17F	DO10843	ESAD	ICGC	VETPKME	DEG_SCF_FBW7_2	0.6667
p.A5S	DO229008	LICA	ICGC	VETPKME	DEG_SCF_FBW7_2	0.3889
p.T2M	DO51112	PRAD	ICGC	VETPKME	DEG_SCF_FBW7_2	0.6389
p.T2M	DO228760	PRAD	ICGC	VETPKME	DEG_SCF_FBW7_2	0.6389
p.E13K	DO229494	SKCA	ICGC	VETPKME	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYM0	Probable ribonuclease ZC3H12B	DEG_SCF_FBW7_2	7:13	VETPKME	FBXW7	0.9593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons