DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SNETGE
Uniprot ID:
Q8NDA2
Source protein:
Hemicentin-2
Source gene:
HMCN2
Class:
DEG_Kelch_Keap1_1
Location:
1535:1540
E3 ligase:
KEAP1
DEGRON score:
0.973
ASA_SCORE:
89.95
COIL:
0.783
CONS_SCORE:
0.6596
DSS_SCORE:
0.4006
HELIX:
0.0267
FCONS_SCORE:
1.7847
RIG_SCORE:
0.7135
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HMCN2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SNETGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDA2
Hemicentin-2
DEG_Kelch_Keap1_1
1535:1540
SNETGE
KEAP1
0.973
More...