DegronMD

Uniprot ID: O43896

Source protein: Kinesin-like protein KIF1C

Source gene: KIF1C

Class: DEG_SIAH_1

Location: 406:414

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.992

ASA_SCORE: 88.9333

COIL: 0.9622

CONS_SCORE: 0.3928

DSS_SCORE: 0.6763

HELIX: 0.0149

FCONS_SCORE: 1.1235

RIG_SCORE: 0.5188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S415P	DO230342	COCA	ICGC	SPPAPVSPS	DEG_SIAH_1	0.3056
p.G421R	SIDM00846	Cervical Carcinoma	GDSC	SPPAPVSPS	DEG_SIAH_1	0.1389
p.G421R	ACH-001086	Cervical Cancer	CCLE	SPPAPVSPS	DEG_SIAH_1	0.1389
p.G421R	HeLa	cervix	COSMIC	SPPAPVSPS	DEG_SIAH_1	0.1389
p.S412A	SIDM00492	Glioblastoma	GDSC	SPPAPVSPS	DEG_SIAH_1	0.7588
p.S412A	SIDM01735	Biliary Tract Carcinoma	GDSC	SPPAPVSPS	DEG_SIAH_1	0.7588
p.S412A	ACH-000269	Brain Cancer	CCLE	SPPAPVSPS	DEG_SIAH_1	0.7588
p.S412A	ACH-000467	Colon/Colorectal Cancer	CCLE	SPPAPVSPS	DEG_SIAH_1	0.7588
p.S412A	ACH-000808	Bile Duct Cancer	CCLE	SPPAPVSPS	DEG_SIAH_1	0.7588
p.S412A	AM-38	central_nervous_system	COSMIC	SPPAPVSPS	DEG_SIAH_1	0.7588
p.S412A	HCC-56	large_intestine	COSMIC	SPPAPVSPS	DEG_SIAH_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43896	Kinesin-like protein KIF1C	DEG_SIAH_1	406:414	SPPAPVSPS	SIAH1,SIAH2,SIAH3	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons