DegronMD - O43896(KIF1C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S415P	DO230342	COCA	ICGC	VRGALPAVS	DEG_APCC_DBOX_1	397:405	Mutation rewiring degron network	0.0556
p.S415P	DO230342	COCA	ICGC	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation rewiring degron network	0.3056
p.T392M	DO228935	COCA	ICGC	VRGALPAVS	DEG_APCC_DBOX_1	397:405	Mutation rewiring degron network	0.1944
p.T392M	DO49448	PACA	ICGC	VRGALPAVS	DEG_APCC_DBOX_1	397:405	Mutation rewiring degron network	0.1944
p.G421R	SIDM00846	Cervical Carcinoma	GDSC	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation rewiring degron network	0.1389
p.G421R	ACH-001086	Cervical Cancer	CCLE	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation rewiring degron network	0.1389
p.G421R	HeLa	cervix	COSMIC	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation rewiring degron network	0.1389
p.S412A	SIDM00492	Glioblastoma	GDSC	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation altering degron motif	0.7588
p.S412A	SIDM01735	Biliary Tract Carcinoma	GDSC	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation altering degron motif	0.7588
p.S412A	ACH-000269	Brain Cancer	CCLE	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation altering degron motif	0.7588
p.S412A	ACH-000467	Colon/Colorectal Cancer	CCLE	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation altering degron motif	0.7588
p.S412A	ACH-000808	Bile Duct Cancer	CCLE	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation altering degron motif	0.7588
p.S412A	AM-38	central nervous system	COSMIC	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation altering degron motif	0.7588
p.S412A	HCC-56	large intestine	COSMIC	SPPAPVSPS	DEG_SIAH_1	406:414	Mutation altering degron motif	0.7588

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons