DegronMD

Uniprot ID: O43896

Source protein: Kinesin-like protein KIF1C

Source gene: KIF1C

Class: DEG_APCC_DBOX_1

Location: 397:405

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9557

ASA_SCORE: 85.8667

COIL: 0.8432

CONS_SCORE: 0.3553

DSS_SCORE: 0.5842

HELIX: 0.0808

FCONS_SCORE: 1.193

RIG_SCORE: 0.6257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S415P	DO230342	COCA	ICGC	VRGALPAVS	DEG_APCC_DBOX_1	0.0556
p.T392M	DO228935	COCA	ICGC	VRGALPAVS	DEG_APCC_DBOX_1	0.1944
p.T392M	DO49448	PACA	ICGC	VRGALPAVS	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43896	Kinesin-like protein KIF1C	DEG_APCC_DBOX_1	397:405	VRGALPAVS	APC,CDC20,FZR1	0.9557	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons