DegronMD

Uniprot ID: Q9H330

Source protein: Transmembrane protein 245

Source gene: TMEM245

Class: DEG_COP1_1

Location: 846:854

E3 ligase: COP1

DEGRON score: 0.8432

ASA_SCORE: 93.2889

COIL: 0.9579

CONS_SCORE: 0.2864

DSS_SCORE: 0.3816

HELIX: 0.0284

FCONS_SCORE: 0.6591

RIG_SCORE: 0.6829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y840F	DO228617	LICA	ICGC	SPTNSVPTP	DEG_COP1_1	0.1667
p.L844I	DO229022	LICA	ICGC	SPTNSVPTP	DEG_COP1_1	0.2778
p.A842D	DO229009	LICA	ICGC	SPTNSVPTP	DEG_COP1_1	0.2222
p.A836T	DO229130	NKTL	ICGC	SPTNSVPTP	DEG_COP1_1	0.0556
p.T853M	SIDM00789	Colorectal Carcinoma	GDSC	SPTNSVPTP	DEG_COP1_1	0.7423
p.T853M	HCT-15	large_intestine	COSMIC	SPTNSVPTP	DEG_COP1_1	0.7423
p.S841N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPTNSVPTP	DEG_COP1_1	0.1944
p.S841N	ACH-001127	Leukemia	CCLE	SPTNSVPTP	DEG_COP1_1	0.1944
p.S841N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SPTNSVPTP	DEG_COP1_1	0.1944
p.P860H	ACH-001061	Colon/Colorectal Cancer	CCLE	SPTNSVPTP	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H330	Transmembrane protein 245	DEG_COP1_1	846:854	SPTNSVPTP	COP1	0.8432	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons