DegronMD - Q9H330(TMEM245)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y840F	DO228617	LICA	ICGC	SPTNSVPTP	DEG_COP1_1	846:854	Mutation rewiring degron network	0.1667
p.L844I	DO229022	LICA	ICGC	SPTNSVPTP	DEG_COP1_1	846:854	Mutation rewiring degron network	0.2778
p.L844I	DO229022	LICA	ICGC	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation rewiring degron network	0.1389
p.A842D	DO229009	LICA	ICGC	SPTNSVPTP	DEG_COP1_1	846:854	Mutation rewiring degron network	0.2222
p.A842D	DO229009	LICA	ICGC	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation rewiring degron network	0.0833
p.Q856R	DO228906	LICA	ICGC	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation altering degron motif	0.6218
p.A836T	DO229130	NKTL	ICGC	SPTNSVPTP	DEG_COP1_1	846:854	Mutation rewiring degron network	0.0556
p.R865W	DO229268	THCA	ICGC	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation rewiring degron network	0.1111
p.T853M	SIDM00789	Colorectal Carcinoma	GDSC	SPTNSVPTP	DEG_COP1_1	846:854	Mutation altering degron motif	0.7423
p.T853M	SIDM00789	Colorectal Carcinoma	GDSC	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation altering degron motif	0.7423
p.T853M	HCT-15	large intestine	COSMIC	SPTNSVPTP	DEG_COP1_1	846:854	Mutation altering degron motif	0.7423
p.T853M	HCT-15	large intestine	COSMIC	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation altering degron motif	0.7423
p.S841N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SPTNSVPTP	DEG_COP1_1	846:854	Mutation rewiring degron network	0.1944
p.S841N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation rewiring degron network	0.0556
p.S841N	ACH-001127	Leukemia	CCLE	SPTNSVPTP	DEG_COP1_1	846:854	Mutation rewiring degron network	0.1944
p.S841N	ACH-001127	Leukemia	CCLE	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation rewiring degron network	0.0556
p.S841N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SPTNSVPTP	DEG_COP1_1	846:854	Mutation rewiring degron network	0.1944
p.S841N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation rewiring degron network	0.0556
p.P860H	ACH-001061	Colon/Colorectal Cancer	CCLE	SPTNSVPTP	DEG_COP1_1	846:854	Mutation rewiring degron network	0.1667
p.P860H	ACH-001061	Colon/Colorectal Cancer	CCLE	VPTPNQT	DEG_SCF_FBW7_1	851:857	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM245

UniProt ID: Q9H330

Entrez ID: 23731

Protein name: Transmembrane protein 245 (Protein CG-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM245 in