DegronMD

Uniprot ID: Q9H330

Source protein: Transmembrane protein 245

Source gene: TMEM245

Class: DEG_SCF_FBW7_1

Location: 851:857

E3 ligase: FBXW7

DEGRON score: 0.6956

ASA_SCORE: 96.1857

COIL: 0.9616

CONS_SCORE: 0.2849

DSS_SCORE: 0.5608

HELIX: 0.0156

FCONS_SCORE: 0.7784

RIG_SCORE: 0.6672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L844I	DO229022	LICA	ICGC	VPTPNQT	DEG_SCF_FBW7_1	0.1389
p.A842D	DO229009	LICA	ICGC	VPTPNQT	DEG_SCF_FBW7_1	0.0833
p.Q856R	DO228906	LICA	ICGC	VPTPNQT	DEG_SCF_FBW7_1	0.6218
p.R865W	DO229268	THCA	ICGC	VPTPNQT	DEG_SCF_FBW7_1	0.1111
p.T853M	SIDM00789	Colorectal Carcinoma	GDSC	VPTPNQT	DEG_SCF_FBW7_1	0.7423
p.T853M	HCT-15	large_intestine	COSMIC	VPTPNQT	DEG_SCF_FBW7_1	0.7423
p.S841N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VPTPNQT	DEG_SCF_FBW7_1	0.0556
p.S841N	ACH-001127	Leukemia	CCLE	VPTPNQT	DEG_SCF_FBW7_1	0.0556
p.S841N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VPTPNQT	DEG_SCF_FBW7_1	0.0556
p.P860H	ACH-001061	Colon/Colorectal Cancer	CCLE	VPTPNQT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H330	Transmembrane protein 245	DEG_SCF_FBW7_1	851:857	VPTPNQT	FBXW7	0.6956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons