DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SPVTHNVPSP
Uniprot ID:
Q8IZP9
Source protein:
Adhesion G-protein coupled receptor G2
Source gene:
ADGRG2
Class:
DEG_COP1_1
Location:
286:295
E3 ligase:
COP1
DEGRON score:
0.9935
ASA_SCORE:
76.12
COIL:
0.8433
CONS_SCORE:
0.3593
DSS_SCORE:
0.6007
HELIX:
0.0166
FCONS_SCORE:
0.963
RIG_SCORE:
0.657
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ADGRG2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SPVTHNVPSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IZP9
Adhesion G-protein coupled receptor G2
DEG_COP1_1
286:295
SPVTHNVPSP
COP1
0.9935
More...