DegronMD

Uniprot ID: Q17RC7

Source protein: Exocyst complex component 3-like protein 4

Source gene: EXOC3L4

Class: DEG_COP1_1

Location: 100:110

E3 ligase: COP1

DEGRON score: 0.8576

ASA_SCORE: 73.8273

COIL: 0.8376

CONS_SCORE: 0.5892

DSS_SCORE: 0.6651

HELIX: 0.0884

FCONS_SCORE: 0.8874

RIG_SCORE: 0.6361

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H99Y	TCGA-BR-7851	STAD	TCGA	SQATPEVPSGV	DEG_COP1_1	0.3056
p.H99Y	DO38711	STAD	ICGC	SQATPEVPSGV	DEG_COP1_1	0.3056
p.E105K	TCGA-FD-A5BX	BLCA	TCGA	SQATPEVPSGV	DEG_COP1_1	0.591
p.E105K	DO44079	BLCA	ICGC	SQATPEVPSGV	DEG_COP1_1	0.591
p.G98D	TCGA-FS-A1YY	SKCM	TCGA	SQATPEVPSGV	DEG_COP1_1	0.2778
p.G98D	DO37415	SKCM	ICGC	SQATPEVPSGV	DEG_COP1_1	0.2778
p.G94D	TCGA-IB-7651	PAAD	TCGA	SQATPEVPSGV	DEG_COP1_1	0.1667
p.G94D	DO46657	PAAD	ICGC	SQATPEVPSGV	DEG_COP1_1	0.1667
p.D93E	DO229010	COCA	ICGC	SQATPEVPSGV	DEG_COP1_1	0.1389
p.D93E	DO229013	COCA	ICGC	SQATPEVPSGV	DEG_COP1_1	0.1389
p.D93E	DO229016	COCA	ICGC	SQATPEVPSGV	DEG_COP1_1	0.1389
p.D93E	DO230993	LUSC	ICGC	SQATPEVPSGV	DEG_COP1_1	0.1389
p.D93E	DO231124	LUSC	ICGC	SQATPEVPSGV	DEG_COP1_1	0.1389
p.S115N	DO234298	ESAD	ICGC	SQATPEVPSGV	DEG_COP1_1	0.1944
p.S119F	DO222494	MELA	ICGC	SQATPEVPSGV	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17RC7	Exocyst complex component 3-like protein 4	DEG_COP1_1	100:110	SQATPEVPSGV	COP1	0.8576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons