DegronMD - Q17RC7(EXOC3L4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R63W	TCGA-BG-A222	UCEC	TCGA	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.0833
p.R63W	DO42977	UCEC	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.0833
p.H99Y	TCGA-BR-7851	STAD	TCGA	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.3056
p.H99Y	DO38711	STAD	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.3056
p.R59W	TCGA-CG-5721	STAD	TCGA	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.1944
p.R59W	DO38192	STAD	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.1944
p.R42C	TCGA-D1-A103	UCEC	TCGA	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.2222
p.R42C	DO42312	UCEC	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.2222
p.E105K	TCGA-FD-A5BX	BLCA	TCGA	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation altering degron motif	0.591
p.E105K	DO44079	BLCA	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation altering degron motif	0.591
p.G98D	TCGA-FS-A1YY	SKCM	TCGA	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.2778
p.G98D	DO37415	SKCM	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.2778
p.G94D	TCGA-IB-7651	PAAD	TCGA	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.1667
p.G94D	DO46657	PAAD	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.1667
p.K43N	TCGA-X9-A971	SARC	TCGA	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation substituting flanking lysine	0.3611
p.K43N	DO220327	SARC	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation substituting flanking lysine	0.3611
p.L50M	DO230335	COCA	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation altering degron motif	0.711
p.D93E	DO229010	COCA	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.1389
p.D93E	DO229013	COCA	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.1389
p.D93E	DO229016	COCA	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.1389
p.D93E	DO230993	LUSC	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.1389
p.D93E	DO231124	LUSC	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.1389
p.S115N	DO234298	ESAD	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.1944
p.G51C	DO229022	LICA	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation altering degron motif	0.6489
p.R47K	DO220906	MELA	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation altering degron motif	0.7237
p.S119F	DO222494	MELA	ICGC	SQATPEVPSGV	DEG_COP1_1	100:110	Mutation rewiring degron network	0.0833
p.F57S	DO229245	THCA	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation rewiring degron network	0.25
p.G49A	ACH-000941	Endometrial/Uterine Cancer	CCLE	TRLGLGSLR	DEG_APCC_DBOX_1	46:54	Mutation altering degron motif	0.6429

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EXOC3L4

UniProt ID: Q17RC7

Entrez ID: 91828

Protein name: Exocyst complex component 3-like protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EXOC3L4 in