DegronMD

Uniprot ID: Q17RC7

Source protein: Exocyst complex component 3-like protein 4

Source gene: EXOC3L4

Class: DEG_APCC_DBOX_1

Location: 46:54

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9062

ASA_SCORE: 69.2889

COIL: 0.4013

CONS_SCORE: 0.7196

DSS_SCORE: 0.6165

HELIX: 0.533

FCONS_SCORE: 1.1514

RIG_SCORE: 0.6852

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R47K	DO220906	MELA	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	0.7237
p.L50M	DO230335	COCA	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	0.711
p.G51C	DO229022	LICA	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	0.6489
p.G49A	ACH-000941	Endometrial/Uterine Cancer	CCLE	TRLGLGSLR	DEG_APCC_DBOX_1	0.6429
p.K43N	TCGA-X9-A971	SARC	TCGA	TRLGLGSLR	DEG_APCC_DBOX_1	0.3611
p.K43N	DO220327	SARC	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	0.3611
p.F57S	DO229245	THCA	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	0.25
p.R42C	TCGA-D1-A103	UCEC	TCGA	TRLGLGSLR	DEG_APCC_DBOX_1	0.2222
p.R42C	DO42312	UCEC	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	0.2222
p.R59W	TCGA-CG-5721	STAD	TCGA	TRLGLGSLR	DEG_APCC_DBOX_1	0.1944
p.R59W	DO38192	STAD	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	0.1944
p.R63W	TCGA-BG-A222	UCEC	TCGA	TRLGLGSLR	DEG_APCC_DBOX_1	0.0833
p.R63W	DO42977	UCEC	ICGC	TRLGLGSLR	DEG_APCC_DBOX_1	0.0833

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17RC7	Exocyst complex component 3-like protein 4	DEG_APCC_DBOX_1	46:54	TRLGLGSLR	APC,CDC20,FZR1	0.9062	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons