DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
SQSRSNVPSA
Uniprot ID:
Q9H992
Source protein:
E3 ubiquitin-protein ligase MARCHF7
Source gene:
MARCHF7
Class:
DEG_COP1_1
Location:
324:333
E3 ligase:
COP1
DEGRON score:
0.8754
ASA_SCORE:
93.92
COIL:
0.892
CONS_SCORE:
0.4379
DSS_SCORE:
0.5586
HELIX:
0.0828
FCONS_SCORE:
0.8577
RIG_SCORE:
0.6075
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MARCHF7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SQSRSNVPSA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H992
E3 ubiquitin-protein ligase MARCHF7
DEG_COP1_1
324:333
SQSRSNVPSA
COP1
0.8754
More...