DegronMD

Uniprot ID: Q5T5Y3

Source protein: Calmodulin-regulated spectrin-associated protein 1

Source gene: CAMSAP1

Class: DEG_APCC_DBOX_1

Location: 1229:1237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9785

ASA_SCORE: 81.8

COIL: 0.6114

CONS_SCORE: 0.4112

DSS_SCORE: 0.4309

HELIX: 0.2897

FCONS_SCORE: 1.0172

RIG_SCORE: 0.7743

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1231C	NCI-H1734	lung	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.7541
p.R1239C	SNU-1040	large_intestine	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.7222
p.V1234M	HCT-15	large_intestine	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.7208
p.D1240A	TCGA-D7-A4YT	STAD	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.25
p.D1240A	DO47723	STAD	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.25
p.V1223M	TCGA-55-5899	LUAD	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	TCGA-D1-A16F	UCEC	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	DO26042	LUAD	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	DO42408	UCEC	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	SIDM00789	Colorectal Carcinoma	GDSC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	ACH-000997	Colon/Colorectal Cancer	CCLE	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	ACH-001061	Colon/Colorectal Cancer	CCLE	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	HCT-15	large_intestine	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.A1243P	TCGA-BR-4362	STAD	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.A1243P	DO38336	STAD	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.P1244A	TCGA-ZF-A9RE	BLCA	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1244A	DO219072	BLCA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1222S	DO233944	GACA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1222S	DO220855	MELA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1222T	DO229022	LICA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1222L	DO220859	MELA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1244L	DO219878	SKCA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.D1245N	TCGA-E6-A1LX	UCEC	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.D1245N	DO41020	UCEC	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.D1245N	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	SRASLIEVD	DEG_APCC_DBOX_1	0.1111

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Drug responses associated with CAMSAP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of SRASLIEVD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_APCC_DBOX_1	1229:1237	SRASLIEVD	APC,CDC20,FZR1	0.9785	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRASLIEVD

Degron related mutations and impact score

Drug responses associated with CAMSAP1 mutations

All proteins holding degron of SRASLIEVD