DegronMD

Uniprot ID: Q5T5Y3

Source protein: Calmodulin-regulated spectrin-associated protein 1

Source gene: CAMSAP1

Class: DEG_APCC_DBOX_1

Location: 1229:1237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9785

ASA_SCORE: 81.8

COIL: 0.6114

CONS_SCORE: 0.4112

DSS_SCORE: 0.4309

HELIX: 0.2897

FCONS_SCORE: 1.0172

RIG_SCORE: 0.7743

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1223M	TCGA-55-5899	LUAD	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	TCGA-D1-A16F	UCEC	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	DO26042	LUAD	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	DO42408	UCEC	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	SIDM00789	Colorectal Carcinoma	GDSC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	ACH-000997	Colon/Colorectal Cancer	CCLE	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	ACH-001061	Colon/Colorectal Cancer	CCLE	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.V1223M	HCT-15	large_intestine	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.S1220I	TCGA-AX-A2HD	UCEC	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.0833
p.S1220I	DO42608	UCEC	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.0833
p.A1243P	TCGA-BR-4362	STAD	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.A1243P	DO38336	STAD	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1667
p.D1240A	TCGA-D7-A4YT	STAD	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.25
p.D1240A	DO47723	STAD	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.25
p.D1245N	TCGA-E6-A1LX	UCEC	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.D1245N	DO41020	UCEC	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.D1245N	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.D1245N	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.D1245N	ACH-000590	Lung Cancer	CCLE	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.D1245N	ACH-001137	Lung Cancer	CCLE	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.D1245N	NCI-H1993	lung	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.1111
p.E1246K	TCGA-EO-A3AZ	UCEC	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.0833
p.E1246K	DO50078	UCEC	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.0833
p.P1244A	TCGA-ZF-A9RE	BLCA	TCGA	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1244A	DO219072	BLCA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1222S	DO233944	GACA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1222S	DO220855	MELA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1222T	DO229022	LICA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.P1222L	DO220859	MELA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.VP1221VS	DO220855	MELA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0
p.D1247E	DO47012	RECA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.0556
p.P1244L	DO219878	SKCA	ICGC	SRASLIEVD	DEG_APCC_DBOX_1	0.1389
p.S1220C	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	SRASLIEVD	DEG_APCC_DBOX_1	0.0833
p.S1220C	ACH-000675	Lung Cancer	CCLE	SRASLIEVD	DEG_APCC_DBOX_1	0.0833
p.S1220C	NCI-H1734	lung	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.0833
p.D1247G	SIDM01135	Pancreatic Carcinoma	GDSC	SRASLIEVD	DEG_APCC_DBOX_1	0.0556
p.D1247G	ACH-000060	Pancreatic Cancer	CCLE	SRASLIEVD	DEG_APCC_DBOX_1	0.0556
p.D1247G	PANC-10-05	pancreas	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.0556
p.V1234M	HCT-15	large_intestine	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.7208
p.S1231C	NCI-H1734	lung	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.7541
p.R1239C	SNU-1040	large_intestine	COSMIC	SRASLIEVD	DEG_APCC_DBOX_1	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRASLIEVD

Degron related mutations and impact score

Drug responses associated with CAMSAP1 mutations

All proteins holding degron of SRASLIEVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_APCC_DBOX_1	1229:1237	SRASLIEVD	APC,CDC20,FZR1	0.9785	More...