DegronMD

Uniprot ID: Q6ZUX3

Source protein: TOG array regulator of axonemal microtubules protein 2

Source gene: TOGARAM2

Class: DEG_APCC_DBOX_1

Location: 432:440

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9023

ASA_SCORE: 99.6889

COIL: 0.9228

CONS_SCORE: 0.3935

DSS_SCORE: 0.2676

HELIX: 0.0557

FCONS_SCORE: 0.9777

RIG_SCORE: 0.7324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R450H	SIDM00689	B-Lymphoblastic Leukemia	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	0.0556
p.L436P	SIDM00210	Ovarian Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	0.7582
p.L436P	SIDM00878	Breast Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	0.7582
p.R433W	SIDM00151	Ovarian Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	0.8634
p.R433W	IGROV-1	ovary	COSMIC	SRASLPSIP	DEG_APCC_DBOX_1	0.8634
p.R443W	SIDM00251	Gastric Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	0.25
p.R443W	TGBC11TKB	stomach	COSMIC	SRASLPSIP	DEG_APCC_DBOX_1	0.25
p.I441L	SIDM01343	Gastric Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZUX3	TOG array regulator of axonemal microtubules protein 2	DEG_APCC_DBOX_1	432:440	SRASLPSIP	APC,CDC20,FZR1	0.9023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons