DegronMD - Q6ZUX3(TOGARAM2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R450H	SIDM00689	B-Lymphoblastic Leukemia	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.0556
p.L436P	SIDM00210	Ovarian Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7582
p.L436P	SIDM00878	Breast Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7582
p.R433W	SIDM00151	Ovarian Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.8634
p.R433W	IGROV-1	ovary	COSMIC	SRASLPSIP	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.8634
p.R443W	SIDM00251	Gastric Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.25
p.R443W	TGBC11TKB	stomach	COSMIC	SRASLPSIP	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.25
p.P198S	SIDM00254	Neuroblastoma	GDSC	IPTTPEAS	DEG_SCF_FBW7_1	181:188	Mutation rewiring degron network	0.0556
p.I441L	SIDM01343	Gastric Carcinoma	GDSC	SRASLPSIP	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons