DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRDALPFLL
Uniprot ID:
Q6AHZ1
Source protein:
Zinc finger protein 518A
Source gene:
ZNF518A
Class:
DEG_APCC_DBOX_1
Location:
1189:1197
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8079
ASA_SCORE:
65.3111
COIL:
0.609
CONS_SCORE:
0.5445
DSS_SCORE:
0.5769
HELIX:
0.2276
FCONS_SCORE:
1.1421
RIG_SCORE:
0.7863
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I1180T
SIDM01724
Melanoma
GDSC
SRDALPFLL
DEG_APCC_DBOX_1
0.0833
Drug responses associated with ZNF518A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRDALPFLL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6AHZ1
Zinc finger protein 518A
DEG_APCC_DBOX_1
1189:1197
SRDALPFLL
APC,CDC20,FZR1
0.8079
More...