DegronMD

Uniprot ID: Q9NYK6

Source protein: Protein EURL homolog

Source gene: EURL

Class: DEG_APCC_DBOX_1

Location: 218:226

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9835

ASA_SCORE: 66.0222

COIL: 0.4679

CONS_SCORE: 0.6777

DSS_SCORE: 0.5778

HELIX: 0.5232

FCONS_SCORE: 1.2067

RIG_SCORE: 0.7018

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S224L	TCGA-A6-2686	COAD	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	TCGA-AJ-A3EL	UCEC	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	TCGA-AP-A1DV	UCEC	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	TCGA-AX-A0J0	UCEC	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	TCGA-B5-A3FC	UCEC	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	TCGA-D1-A3DH	UCEC	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	TCGA-E6-A1LX	UCEC	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	TCGA-EO-A22X	UCEC	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	TCGA-EY-A1GI	UCEC	TCGA	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO7828	COAD	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO8898	COAD	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO222798	COCA	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO36881	READ	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO43482	UCEC	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO41020	UCEC	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO43186	UCEC	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO41542	UCEC	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO41871	UCEC	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO43907	UCEC	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO41211	UCEC	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	DO41133	UCEC	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	SIDM01288	Colorectal Carcinoma	GDSC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	SIDM00878	Breast Carcinoma	GDSC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	SIDM00954	Breast Carcinoma	GDSC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	SIDM00534	Colorectal Carcinoma	GDSC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	SIDM00118	Colorectal Carcinoma	GDSC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	SIDM01588	Endometrial Carcinoma	GDSC	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	ACH-000930	Breast Cancer	CCLE	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	ACH-000986	Colon/Colorectal Cancer	CCLE	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	ACH-000993	Endometrial/Uterine Cancer	CCLE	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	ACH-001081	Colon/Colorectal Cancer	CCLE	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.S224L	ACH-001820	Breast Cancer	CCLE	SREELNSMT	DEG_APCC_DBOX_1	0.6556
p.T226S	DO228848	LICA	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.6005
p.Q213K	DO229031	LICA	ICGC	SREELNSMT	DEG_APCC_DBOX_1	0.1944
p.A235V	SIDM00217	Colorectal Carcinoma	GDSC	SREELNSMT	DEG_APCC_DBOX_1	0.0833
p.A235V	ACH-000999	Colon/Colorectal Cancer	CCLE	SREELNSMT	DEG_APCC_DBOX_1	0.0833
p.E220D	ACH-001520	Leukemia	CCLE	SREELNSMT	DEG_APCC_DBOX_1	0.5647

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SREELNSMT

Degron related mutations and impact score

Drug responses associated with EURL mutations

All proteins holding degron of SREELNSMT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYK6	Protein EURL homolog	DEG_APCC_DBOX_1	218:226	SREELNSMT	APC,CDC20,FZR1	0.9835	More...