DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
SREKLEELP
Uniprot ID:
Q8WVS4
Source protein:
Cytoplasmic dynein 2 intermediate chain 1
Source gene:
DYNC2I1
Class:
DEG_APCC_DBOX_1
Location:
401:409
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9483
ASA_SCORE:
98.4
COIL:
0.5743
CONS_SCORE:
0.3
DSS_SCORE:
0.6477
HELIX:
0.4199
FCONS_SCORE:
1.0435
RIG_SCORE:
0.7187
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DYNC2I1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SREKLEELP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WVS4
Cytoplasmic dynein 2 intermediate chain 1
DEG_APCC_DBOX_1
401:409
SREKLEELP
APC,CDC20,FZR1
0.9483
More...