DegronMD

Uniprot ID: Q96L93

Source protein: Kinesin-like protein KIF16B

Source gene: KIF16B

Class: DEG_APCC_DBOX_1

Location: 582:590

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5257

ASA_SCORE: 58.3222

COIL: 0.4334

CONS_SCORE: 0.2773

DSS_SCORE: 0.3055

HELIX: 0.4627

FCONS_SCORE: 0.9848

RIG_SCORE: 0.7398

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T577I	TCGA-3B-A9HS	SARC	TCGA	SRENLSAVM	DEG_APCC_DBOX_1	0.6389
p.T577I	DO219933	SARC	ICGC	SRENLSAVM	DEG_APCC_DBOX_1	0.6389
p.M590L	TCGA-50-5946	LUAD	TCGA	SRENLSAVM	DEG_APCC_DBOX_1	0.5999
p.M590L	DO24556	LUAD	ICGC	SRENLSAVM	DEG_APCC_DBOX_1	0.5999
p.A588T	TCGA-AX-A1CE	UCEC	TCGA	SRENLSAVM	DEG_APCC_DBOX_1	0.6028
p.A588T	DO42280	UCEC	ICGC	SRENLSAVM	DEG_APCC_DBOX_1	0.6028
p.R583S	TCGA-D9-A148	SKCM	TCGA	SRENLSAVM	DEG_APCC_DBOX_1	0.7427
p.R583S	DO37971	SKCM	ICGC	SRENLSAVM	DEG_APCC_DBOX_1	0.7427
p.E599K	TCGA-DK-A1AC	BLCA	TCGA	SRENLSAVM	DEG_APCC_DBOX_1	0.0833
p.E599K	DO514	BLCA	ICGC	SRENLSAVM	DEG_APCC_DBOX_1	0.0833
p.G595R	TCGA-DU-6392	LGG	TCGA	SRENLSAVM	DEG_APCC_DBOX_1	0.1944
p.G595R	DO22237	LGG	ICGC	SRENLSAVM	DEG_APCC_DBOX_1	0.1944
p.G595R	SIDM00214	Colorectal Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.1944
p.G595R	SNU-407	large_intestine	COSMIC	SRENLSAVM	DEG_APCC_DBOX_1	0.1944
p.G595E	TCGA-FW-A3R5	SKCM	TCGA	SRENLSAVM	DEG_APCC_DBOX_1	0.1944
p.G595E	DO37406	SKCM	ICGC	SRENLSAVM	DEG_APCC_DBOX_1	0.1944
p.S580L	DO227646	COCA	ICGC	SRENLSAVM	DEG_APCC_DBOX_1	0.7222
p.R583H	SIDM00557	Neuroblastoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00586	Hepatocellular Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00608	Plasma Cell Myeloma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00588	Oral Cavity Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM01242	Melanoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM01247	Burkitt's Lymphoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00596	Endometrial Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00252	Biliary Tract Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00214	Colorectal Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00242	Osteosarcoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00612	Glioma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00609	Kidney Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00996	Thyroid Gland Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM01551	Gastric Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM01460	Glioma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00163	Biliary Tract Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM01450	Gastric Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.R583H	SIDM00016	Neuroblastoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.8244
p.N585T	SIDM01117	Small Cell Lung Carcinoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.5944
p.F572L	SIDM00581	Glioblastoma	GDSC	SRENLSAVM	DEG_APCC_DBOX_1	0.0556
p.F572L	ACH-000738	Brain Cancer	CCLE	SRENLSAVM	DEG_APCC_DBOX_1	0.0556
p.F572L	GB-1	central_nervous_system	COSMIC	SRENLSAVM	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRENLSAVM

Degron related mutations and impact score

Drug responses associated with KIF16B mutations

All proteins holding degron of SRENLSAVM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L93	Kinesin-like protein KIF16B	DEG_APCC_DBOX_1	582:590	SRENLSAVM	APC,CDC20,FZR1	0.5257	More...