DegronMD

Uniprot ID: Q14566

Source protein: DNA replication licensing factor MCM6

Source gene: MCM6

Class: DEG_APCC_DBOX_1

Location: 528:536

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6402

ASA_SCORE: 27.6889

COIL: 0.4328

CONS_SCORE: 0.8535

DSS_SCORE: 0.017

HELIX: 0.0171

FCONS_SCORE: 1.3404

RIG_SCORE: 0.9628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D531N	TCGA-AG-A002	READ	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	0.5821
p.D531N	TCGA-BK-A6W3	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	0.5821
p.D531N	DO50076	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.5821
p.E542D	TCGA-AP-A059	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	0.1667
p.E542D	DO41361	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.1667
p.R529Q	TCGA-AX-A05Z	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	0.7329
p.R529Q	TCGA-ER-A19F	SKCM	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	0.7329
p.R529Q	DO50441	ESAD	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.7329
p.R529Q	DO37679	SKCM	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.7329
p.R529Q	DO40884	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.7329
p.L536I	TCGA-B5-A1MR	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	0.6063
p.L536I	DO41758	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.6063
p.A524T	TCGA-DI-A1BU	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	0.2222
p.A524T	DO42023	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.2222
p.L536F	TCGA-YD-A9TA	SKCM	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	0.587
p.L536F	DO219503	SKCM	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.587
p.D531V	DO228786	LICA	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	0.6674
p.D545Y	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	SRFDLFFIL	DEG_APCC_DBOX_1	0.0833
p.D545Y	ACH-000875	Lung Cancer	CCLE	SRFDLFFIL	DEG_APCC_DBOX_1	0.0833
p.D545Y	NCI-H2347	lung	COSMIC	SRFDLFFIL	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14566	DNA replication licensing factor MCM6	DEG_APCC_DBOX_1	528:536	SRFDLFFIL	APC,CDC20,FZR1	0.6402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons