DegronMD - Q14566(MCM6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S258R	TCGA-61-2614	OV	TCGA	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation blocking phosphorylation signal	0.6667
p.S258R	DO27995	OV	ICGC	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation blocking phosphorylation signal	0.6667
p.D531N	TCGA-AG-A002	READ	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.5821
p.D531N	TCGA-BK-A6W3	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.5821
p.D531N	DO50076	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.5821
p.E542D	TCGA-AP-A059	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation rewiring degron network	0.1667
p.E542D	DO41361	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation rewiring degron network	0.1667
p.R529Q	TCGA-AX-A05Z	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.7329
p.R529Q	TCGA-ER-A19F	SKCM	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.7329
p.R529Q	DO50441	ESAD	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.7329
p.R529Q	DO37679	SKCM	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.7329
p.R529Q	DO40884	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.7329
p.V254I	TCGA-AX-A2HD	UCEC	TCGA	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation altering degron motif	0.5965
p.V254I	DO42608	UCEC	ICGC	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation altering degron motif	0.5965
p.L536I	TCGA-B5-A1MR	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.6063
p.L536I	DO41758	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.6063
p.A524T	TCGA-DI-A1BU	UCEC	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation rewiring degron network	0.2222
p.A524T	DO42023	UCEC	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation rewiring degron network	0.2222
p.L257F	TCGA-VQ-A8P2	STAD	TCGA	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation rewiring degron network	0.25
p.L257F	DO51761	STAD	ICGC	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation rewiring degron network	0.25
p.L536F	TCGA-YD-A9TA	SKCM	TCGA	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.587
p.L536F	DO219503	SKCM	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.587
p.R263C	DO233245	GACA	ICGC	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation rewiring degron network	0.0833
p.D531V	DO228786	LICA	ICGC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation altering degron motif	0.6674
p.P260Q	DO229037	LICA	ICGC	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation rewiring degron network	0.1667
p.T245K	DO50917	LICA	ICGC	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation altering degron motif	0.7306
p.T259I	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation blocking phosphorylation signal	0.6389
p.D545Y	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation rewiring degron network	0.0833
p.D545Y	ACH-000875	Lung Cancer	CCLE	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation rewiring degron network	0.0833
p.D545Y	NCI-H2347	lung	COSMIC	SRFDLFFIL	DEG_APCC_DBOX_1	528:536	Mutation rewiring degron network	0.0833
p.P260L	ACH-000571	Brain Cancer	CCLE	TGTLIVVPDV	DEG_COP1_1	245:254	Mutation rewiring degron network	0.1667

Kaplan plot for MCM6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM6

UniProt ID: Q14566

Entrez ID: 4175

Protein name: DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM6 in