DegronMD

Uniprot ID: Q14566

Source protein: DNA replication licensing factor MCM6

Source gene: MCM6

Class: DEG_COP1_1

Location: 245:254

E3 ligase: COP1

DEGRON score: 0.614

ASA_SCORE: 36.02

COIL: 0.3082

CONS_SCORE: 0.6849

DSS_SCORE: 0.2812

HELIX: 0.0509

FCONS_SCORE: 1.2411

RIG_SCORE: 0.8585

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S258R	TCGA-61-2614	OV	TCGA	TGTLIVVPDV	DEG_COP1_1	0.6667
p.S258R	DO27995	OV	ICGC	TGTLIVVPDV	DEG_COP1_1	0.6667
p.V254I	TCGA-AX-A2HD	UCEC	TCGA	TGTLIVVPDV	DEG_COP1_1	0.5965
p.V254I	DO42608	UCEC	ICGC	TGTLIVVPDV	DEG_COP1_1	0.5965
p.L257F	TCGA-VQ-A8P2	STAD	TCGA	TGTLIVVPDV	DEG_COP1_1	0.25
p.L257F	DO51761	STAD	ICGC	TGTLIVVPDV	DEG_COP1_1	0.25
p.R263C	DO233245	GACA	ICGC	TGTLIVVPDV	DEG_COP1_1	0.0833
p.P260Q	DO229037	LICA	ICGC	TGTLIVVPDV	DEG_COP1_1	0.1667
p.T245K	DO50917	LICA	ICGC	TGTLIVVPDV	DEG_COP1_1	0.7306
p.T259I	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	TGTLIVVPDV	DEG_COP1_1	0.6389
p.P260L	ACH-000571	Brain Cancer	CCLE	TGTLIVVPDV	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14566	DNA replication licensing factor MCM6	DEG_COP1_1	245:254	TGTLIVVPDV	COP1	0.614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons