DegronMD

Uniprot ID: P10244

Source protein: Myb-related protein B

Source gene: MYBL2

Class: DEG_APCC_DBOX_1

Location: 385:393

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9867

ASA_SCORE: 74.4667

COIL: 0.6953

CONS_SCORE: 0.3382

DSS_SCORE: 0.5531

HELIX: 0.0224

FCONS_SCORE: 1.1241

RIG_SCORE: 0.6698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G400C	TCGA-17-Z016	LUAD	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	0.1389
p.S395C	TCGA-38-4626	LUAD	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	0.2778
p.G387S	TCGA-JW-A5VL	CESC	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	0.5882
p.G387D	TCGA-JW-A5VL	CESC	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	0.6087
p.S401C	TCGA-XF-A8HE	BLCA	TCGA	SRGELIPIS	DEG_APCC_DBOX_1	0.1111
p.S377C	DO49797	BLCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.1111
p.S403G	DO228483	BRCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.0556
p.S403G	DO229010	COCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.0556
p.S403G	DO229003	COCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.0556
p.S403G	DO234285	ESAD	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.0556
p.S403G	DO229480	LAML	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.0556
p.R393C	DO223732	CESC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.8301
p.R393C	DO51407	PRAD	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.8301
p.E401K	DO219067	HNSC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.1111
p.E401K	DO39024	THCA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.1111
p.G376V	DO228974	LICA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.0833
p.G378V	DO229006	LICA	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.1389
p.S403N	DO48701	LIRI	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.0556
p.A395S	DO26414	LUAD	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.2778
p.R393H	DO26772	LUSC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.8244
p.G380D	DO37966	SKCM	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.1944
p.P383L	DO47563	SKCM	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.2778
p.P383L	SW684	soft_tissue	COSMIC	SRGELIPIS	DEG_APCC_DBOX_1	0.2778
p.T381A	DO47563	SKCM	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.2222
p.R388Q	DO223286	UCEC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.7329
p.R388W	DO41331	UCEC	ICGC	SRGELIPIS	DEG_APCC_DBOX_1	0.8634
p.A395G	NCI-H727	lung	COSMIC	SRGELIPIS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10244	Myb-related protein B	DEG_APCC_DBOX_1	385:393	SRGELIPIS	APC,CDC20,FZR1	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRGELIPIS

Degron related mutations and impact score

Drug responses associated with MYBL2 mutations

All proteins holding degron of SRGELIPIS