DegronMD

Uniprot ID: Q8IWE2

Source protein: Protein NOXP20

Source gene: FAM114A1

Class: DEG_APCC_DBOX_1

Location: 205:213

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9892

ASA_SCORE: 61.7

COIL: 0.4357

CONS_SCORE: 0.437

DSS_SCORE: 0.503

HELIX: 0.5328

FCONS_SCORE: 1.0911

RIG_SCORE: 0.692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S205A	TCGA-59-2352	OV	TCGA	SRGMLSAIT	DEG_APCC_DBOX_1	0.6477
p.S205A	DO28068	OV	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.6477
p.R206L	TCGA-66-2766	LUSC	TCGA	SRGMLSAIT	DEG_APCC_DBOX_1	0.8428
p.P197L	TCGA-CA-5796	COAD	TCGA	SRGMLSAIT	DEG_APCC_DBOX_1	0.1111
p.P197L	DO7777	COAD	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.1111
p.S202L	TCGA-G2-A2EO	BLCA	TCGA	SRGMLSAIT	DEG_APCC_DBOX_1	0.6944
p.S202L	DO456	BLCA	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.6944
p.P198R	DO225337	BRCA	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.1389
p.A201S	DO229015	LICA	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.2222
p.K202E	DO48692	LIRI	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.6944
p.P220R	DO219219	LUSC	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.1389
p.A201V	DO51679	PAAD	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.2222
p.S217F	DO41235	UCEC	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	0.2222
p.S210F	SIDM00545	Melanoma	GDSC	SRGMLSAIT	DEG_APCC_DBOX_1	0.7982
p.S210F	ACH-000987	Skin Cancer	CCLE	SRGMLSAIT	DEG_APCC_DBOX_1	0.7982
p.S210F	Mewo	skin	COSMIC	SRGMLSAIT	DEG_APCC_DBOX_1	0.7982
p.S205F	SIDM00007	Other Solid Cancers	GDSC	SRGMLSAIT	DEG_APCC_DBOX_1	0.6871
p.S205F	ACH-001550	Skin Cancer	CCLE	SRGMLSAIT	DEG_APCC_DBOX_1	0.6871
p.S205F	MCC13	skin	COSMIC	SRGMLSAIT	DEG_APCC_DBOX_1	0.6871
p.V223A	SIDM01154	T-Lymphoblastic Leukemia	GDSC	SRGMLSAIT	DEG_APCC_DBOX_1	0.0556
p.V223A	ACH-000953	Leukemia	CCLE	SRGMLSAIT	DEG_APCC_DBOX_1	0.0556
p.V223A	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SRGMLSAIT	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWE2	Protein NOXP20	DEG_APCC_DBOX_1	205:213	SRGMLSAIT	APC,CDC20,FZR1	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons