DegronMD - Q8IWE2(FAM114A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A194S	TCGA-05-4397	LUAD	TCGA	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0556
p.A194S	DO25320	LUAD	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0556
p.S205A	TCGA-59-2352	OV	TCGA	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.6477
p.S205A	DO28068	OV	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.6477
p.R206L	TCGA-66-2766	LUSC	TCGA	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.8428
p.P197L	TCGA-CA-5796	COAD	TCGA	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1111
p.P197L	DO7777	COAD	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1111
p.E183K	TCGA-E2-A1IN	BRCA	TCGA	TENGVPEI	DEG_COP1_1	177:184	Mutation altering degron motif	0.7022
p.E183K	DO3134	BRCA	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation altering degron motif	0.7022
p.P193T	TCGA-EE-A29E	SKCM	TCGA	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0833
p.P193T	DO37831	SKCM	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0833
p.S202L	TCGA-G2-A2EO	BLCA	TCGA	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation blocking phosphorylation signal	0.6944
p.S202L	DO456	BLCA	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation blocking phosphorylation signal	0.6944
p.G168R	TCGA-OD-A75X	SKCM	TCGA	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0833
p.G168R	DO48601	SKCM	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0833
p.G192V	TCGA-QK-A8Z8	HNSC	TCGA	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.1111
p.G192V	DO52097	HNSC	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.1111
p.P193S	TCGA-TQ-A7RV	LGG	TCGA	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0833
p.P193S	DO223699	LGG	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0833
p.P198R	DO225337	BRCA	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1389
p.A201S	DO229015	LICA	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.2222
p.D192Y	DO229015	LICA	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.1111
p.K202E	DO48692	LIRI	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation blocking phosphorylation signal	0.6944
p.P220R	DO219219	LUSC	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.1389
p.A201V	DO51679	PAAD	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.2222
p.T194I	DO37519	SKCM	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.0556
p.A181V	DO37591	SKCM	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation altering degron motif	0.6936
p.S217F	DO41235	UCEC	ICGC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.2222
p.E191D	DO42713	UCEC	ICGC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.1389
p.S210F	SIDM00545	Melanoma	GDSC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.7982
p.S210F	ACH-000987	Skin Cancer	CCLE	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.7982
p.S210F	Mewo	skin	COSMIC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.7982
p.S205F	SIDM00007	Other Solid Cancers	GDSC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.6871
p.S205F	ACH-001550	Skin Cancer	CCLE	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.6871
p.S205F	MCC13	skin	COSMIC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation altering degron motif	0.6871
p.V223A	SIDM01154	T-Lymphoblastic Leukemia	GDSC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.0556
p.V223A	ACH-000953	Leukemia	CCLE	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.0556
p.V223A	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	SRGMLSAIT	DEG_APCC_DBOX_1	205:213	Mutation rewiring degron network	0.0556
p.T177S	SIDM00487	Colorectal Carcinoma	GDSC	TENGVPEI	DEG_COP1_1	177:184	Mutation altering degron motif	0.7116
p.T177S	SIDM01694	B-Lymphoblastic Leukemia	GDSC	TENGVPEI	DEG_COP1_1	177:184	Mutation altering degron motif	0.7116
p.N176D	SIDM01729	Endometrial Carcinoma	GDSC	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.3056
p.N176D	ACH-000909	Endometrial/Uterine Cancer	CCLE	TENGVPEI	DEG_COP1_1	177:184	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM114A1

UniProt ID: Q8IWE2

Entrez ID: 92689

Protein name: Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM114A1 in