DegronMD

Uniprot ID: Q8IWE2

Source protein: Protein NOXP20

Source gene: FAM114A1

Class: DEG_COP1_1

Location: 177:184

E3 ligase: COP1

DEGRON score: 0.6859

ASA_SCORE: 92.1

COIL: 0.8793

CONS_SCORE: 0.3108

DSS_SCORE: 0.7771

HELIX: 0.0764

FCONS_SCORE: 0.8902

RIG_SCORE: 0.6327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A194S	TCGA-05-4397	LUAD	TCGA	TENGVPEI	DEG_COP1_1	0.0556
p.A194S	DO25320	LUAD	ICGC	TENGVPEI	DEG_COP1_1	0.0556
p.E183K	TCGA-E2-A1IN	BRCA	TCGA	TENGVPEI	DEG_COP1_1	0.7022
p.E183K	DO3134	BRCA	ICGC	TENGVPEI	DEG_COP1_1	0.7022
p.P193T	TCGA-EE-A29E	SKCM	TCGA	TENGVPEI	DEG_COP1_1	0.0833
p.P193T	DO37831	SKCM	ICGC	TENGVPEI	DEG_COP1_1	0.0833
p.G168R	TCGA-OD-A75X	SKCM	TCGA	TENGVPEI	DEG_COP1_1	0.0833
p.G168R	DO48601	SKCM	ICGC	TENGVPEI	DEG_COP1_1	0.0833
p.G192V	TCGA-QK-A8Z8	HNSC	TCGA	TENGVPEI	DEG_COP1_1	0.1111
p.G192V	DO52097	HNSC	ICGC	TENGVPEI	DEG_COP1_1	0.1111
p.P193S	TCGA-TQ-A7RV	LGG	TCGA	TENGVPEI	DEG_COP1_1	0.0833
p.P193S	DO223699	LGG	ICGC	TENGVPEI	DEG_COP1_1	0.0833
p.D192Y	DO229015	LICA	ICGC	TENGVPEI	DEG_COP1_1	0.1111
p.T194I	DO37519	SKCM	ICGC	TENGVPEI	DEG_COP1_1	0.0556
p.A181V	DO37591	SKCM	ICGC	TENGVPEI	DEG_COP1_1	0.6936
p.E191D	DO42713	UCEC	ICGC	TENGVPEI	DEG_COP1_1	0.1389
p.T177S	SIDM00487	Colorectal Carcinoma	GDSC	TENGVPEI	DEG_COP1_1	0.7116
p.T177S	SIDM01694	B-Lymphoblastic Leukemia	GDSC	TENGVPEI	DEG_COP1_1	0.7116
p.N176D	SIDM01729	Endometrial Carcinoma	GDSC	TENGVPEI	DEG_COP1_1	0.3056
p.N176D	ACH-000909	Endometrial/Uterine Cancer	CCLE	TENGVPEI	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWE2	Protein NOXP20	DEG_COP1_1	177:184	TENGVPEI	COP1	0.6859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons