DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRKKLDQMR
Uniprot ID:
A6QL64
Source protein:
Ankyrin repeat domain-containing protein 36A
Source gene:
ANKRD36
Class:
DEG_APCC_DBOX_1
Location:
1843:1851
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6291
ASA_SCORE:
99.8556
COIL:
0.0358
CONS_SCORE:
0.2909
DSS_SCORE:
0.5067
HELIX:
0.9668
FCONS_SCORE:
1.0771
RIG_SCORE:
0.755
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ANKRD36 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRKKLDQMR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6QL64
Ankyrin repeat domain-containing protein 36A
DEG_APCC_DBOX_1
1843:1851
SRKKLDQMR
APC,CDC20,FZR1
0.6291
More...