DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRMSLRKMD
Uniprot ID:
Q96N67
Source protein:
Dedicator of cytokinesis protein 7
Source gene:
DOCK7
Class:
DEG_APCC_DBOX_1
Location:
2131:2139
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8359
ASA_SCORE:
90.4889
COIL:
0.526
CONS_SCORE:
0.2423
DSS_SCORE:
0.5578
HELIX:
0.3549
FCONS_SCORE:
0.9806
RIG_SCORE:
0.7854
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DOCK7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRMSLRKMD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96N67
Dedicator of cytokinesis protein 7
DEG_APCC_DBOX_1
2131:2139
SRMSLRKMD
APC,CDC20,FZR1
0.8359
More...