DegronMD

Uniprot ID: Q4KMQ2

Source protein: Anoctamin-6

Source gene: ANO6

Class: DEG_APCC_DBOX_1

Location: 5:13

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7662

ASA_SCORE: 114.5556

COIL: 0.7294

CONS_SCORE: 0.3195

DSS_SCORE: 0.6557

HELIX: 0.2409

FCONS_SCORE: 0.9397

RIG_SCORE: 0.7669

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G21V	TCGA-D3-A2J8	SKCM	TCGA	SRNVLLQME	DEG_APCC_DBOX_1	0.1111
p.G21V	DO37778	SKCM	ICGC	SRNVLLQME	DEG_APCC_DBOX_1	0.1111
p.E16D	TCGA-VS-A9UZ	CESC	TCGA	SRNVLLQME	DEG_APCC_DBOX_1	0.25
p.E16D	DO51646	CESC	ICGC	SRNVLLQME	DEG_APCC_DBOX_1	0.25
p.N7I	DO222608	BTCA	ICGC	SRNVLLQME	DEG_APCC_DBOX_1	0.6169
p.E22K	DO8890	COAD	ICGC	SRNVLLQME	DEG_APCC_DBOX_1	0.0833
p.S5N	SIDM00625	Other Sarcomas	GDSC	SRNVLLQME	DEG_APCC_DBOX_1	0.5958
p.S5N	ACH-000449	Sarcoma	CCLE	SRNVLLQME	DEG_APCC_DBOX_1	0.5958
p.S5N	MES-SA	soft_tissue	COSMIC	SRNVLLQME	DEG_APCC_DBOX_1	0.5958
p.M12I	ACH-000979	Prostate Cancer	CCLE	SRNVLLQME	DEG_APCC_DBOX_1	0.6507
p.S23C	GP5d	large_intestine	COSMIC	SRNVLLQME	DEG_APCC_DBOX_1	0.0556
p.N9S	EN	endometrium	COSMIC	SRNVLLQME	DEG_APCC_DBOX_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4KMQ2	Anoctamin-6	DEG_APCC_DBOX_1	5:13	SRNVLLQME	APC,CDC20,FZR1	0.7662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons