DegronMD

Uniprot ID: Q5VUA4

Source protein: Zinc finger protein 318

Source gene: ZNF318

Class: DEG_APCC_DBOX_1

Location: 831:839

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9828

ASA_SCORE: 85.6556

COIL: 0.8601

CONS_SCORE: 0.4509

DSS_SCORE: 0.6724

HELIX: 0.0442

FCONS_SCORE: 1.1813

RIG_SCORE: 0.6966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K847N	TCGA-63-A5MB	LUSC	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	0.2222
p.K847N	DO52018	LUSC	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.2222
p.R830C	TCGA-CD-8527	STAD	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	0.3056
p.R830C	DO47739	STAD	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.3056
p.Q848H	TCGA-E2-A1LA	BRCA	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	0.0833
p.Q848H	DO3164	BRCA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.0833
p.R836C	TCGA-FW-A3R5	SKCM	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	0.719
p.R836C	DO37406	SKCM	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.719
p.V837M	TCGA-QG-A5Z2	COAD	TCGA	SRPNLRVIP	DEG_APCC_DBOX_1	0.6097
p.V837M	DO44096	COAD	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.6097
p.P823T	DO229022	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.1111
p.P823T	DO229038	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.1111
p.T842N	DO229026	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.6944
p.A828D	DO229026	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.25
p.R832S	DO229008	LICA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.7427
p.T825I	DO219878	SKCA	ICGC	SRPNLRVIP	DEG_APCC_DBOX_1	0.6111
p.A828T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRPNLRVIP	DEG_APCC_DBOX_1	0.25
p.A828T	ACH-000981	Leukemia	CCLE	SRPNLRVIP	DEG_APCC_DBOX_1	0.25
p.A828T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	SRPNLRVIP	DEG_APCC_DBOX_1	0.25
p.K826R	SIDM00272	Breast Carcinoma	GDSC	SRPNLRVIP	DEG_APCC_DBOX_1	0.3056
p.K826R	ACH-000910	Breast Cancer	CCLE	SRPNLRVIP	DEG_APCC_DBOX_1	0.3056
p.K826R	MDA-MB-453	breast	COSMIC	SRPNLRVIP	DEG_APCC_DBOX_1	0.3056
p.I838V	ACH-002287	Colon/Colorectal Cancer	CCLE	SRPNLRVIP	DEG_APCC_DBOX_1	0.5965
p.I838V	NCI-H630	large_intestine	COSMIC	SRPNLRVIP	DEG_APCC_DBOX_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VUA4	Zinc finger protein 318	DEG_APCC_DBOX_1	831:839	SRPNLRVIP	APC,CDC20,FZR1	0.9828	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons