DegronMD

Uniprot ID: Q6P6B1

Source protein: Glutamate-rich protein 5

Source gene: ERICH5

Class: DEG_APCC_DBOX_1

Location: 58:66

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9432

ASA_SCORE: 108.2444

COIL: 0.9059

CONS_SCORE: 0.7293

DSS_SCORE: 0.6625

HELIX: 0.0487

FCONS_SCORE: 0.9629

RIG_SCORE: 0.6815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D51H	SIDM00745	Non-Small Cell Lung Carcinoma	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.1389
p.D51H	NCI-H1650	lung	COSMIC	SRPPLQKLK	DEG_APCC_DBOX_1	0.1389
p.R59H	SIDM00875	Breast Carcinoma	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.8244
p.R59H	SIDM01133	Other Solid Cancers	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.8244
p.R59H	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.8244
p.R59H	SIDM00673	Breast Carcinoma	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.8244
p.R59H	SIDM01173	Rhabdomyosarcoma	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.8244
p.R59H	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.8244
p.R59H	SIDM01752	Pancreatic Carcinoma	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.8244
p.V54I	SIDM01617	Endometrial Carcinoma	GDSC	SRPPLQKLK	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P6B1	Glutamate-rich protein 5	DEG_APCC_DBOX_1	58:66	SRPPLQKLK	APC,CDC20,FZR1	0.9432	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons