DegronMD

Uniprot ID: Q6UXG3

Source protein: CMRF35-like molecule 9

Source gene: CD300LG

Class: DEG_APCC_DBOX_1

Location: 84:92

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5222

ASA_SCORE: 52.9

COIL: 0.4301

CONS_SCORE: 0.5521

DSS_SCORE: 0.1169

HELIX: 0.0292

FCONS_SCORE: 0.7746

RIG_SCORE: 0.8733

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A102V	TCGA-A5-A0G2	UCEC	TCGA	SRQELSLIV	DEG_APCC_DBOX_1	0.0556
p.A102V	DO41235	UCEC	ICGC	SRQELSLIV	DEG_APCC_DBOX_1	0.0556
p.K76Q	TCGA-E6-A1LX	UCEC	TCGA	SRQELSLIV	DEG_APCC_DBOX_1	0.2222
p.K76Q	DO41020	UCEC	ICGC	SRQELSLIV	DEG_APCC_DBOX_1	0.2222
p.T98I	TCGA-W3-AA1W	SKCM	TCGA	SRQELSLIV	DEG_APCC_DBOX_1	0.1667
p.T98I	DO51277	SKCM	ICGC	SRQELSLIV	DEG_APCC_DBOX_1	0.1667
p.R85H	DO227802	COCA	ICGC	SRQELSLIV	DEG_APCC_DBOX_1	0.8244
p.R85H	SIDM01133	Other Solid Cancers	GDSC	SRQELSLIV	DEG_APCC_DBOX_1	0.8244
p.S84C	DO228278	LICA	ICGC	SRQELSLIV	DEG_APCC_DBOX_1	0.643
p.L97I	SIDM01144	Gastric Carcinoma	GDSC	SRQELSLIV	DEG_APCC_DBOX_1	0.1944
p.L97I	ACH-000303	Gastric Cancer	CCLE	SRQELSLIV	DEG_APCC_DBOX_1	0.1944
p.L97I	NCI-SNU-5	stomach	COSMIC	SRQELSLIV	DEG_APCC_DBOX_1	0.1944
p.A102P	ACH-000868	Lung Cancer	CCLE	SRQELSLIV	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXG3	CMRF35-like molecule 9	DEG_APCC_DBOX_1	84:92	SRQELSLIV	APC,CDC20,FZR1	0.5222	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons